Proteomics Weekly

Alzheimer Disease Pathogenesis - LDL receptor-related protein overexpression linked to memory deficits

Parkinson Disease - Alpha-synuclein overexpression involved in familial Parkinson disease

DNA Repair - Lack of repair of 8-oxoguanine involved in some DNA repair diseases

Multiple Sclerosis - MHC- and TCR-binding residues of myelin glycoprotein peptide characterized

Muscular Dystrophy - Surprising new functions found for the nuclear membrane protein emerin

von Willebrand Disease - Mutation disrupts interaction of von Willebrand factor with platelets

Age-Related Macular Degeneration - Endoglin is highly expressed in eyes with choroidal neovascularization

Alzheimer Disease - Chondroitin sulfate of appican interacts with neuroregulatory factors

Alzheimer Disease - Selective BACE-1 inhibitors synthesized

Alzheimer Disease - Synaptic frailty and vesicle trafficking in Alzheimer disease reviewed

Alzheimer Disease Therapy - Microglial activation facilitates A-beta plaque removal

Apoptosis - Green fluorescent protein causes mitochondria to aggregate with Bcl-2

Aspergillus - Cleavage of precursor enzyme causes amylase secretion by Aspergillus

Bacteriology - Bacteria manipulate Rho to enhance their survival

Bovine Spongiform Encephalopathy - Britain restricts blood donations as a precaution against mad cow's disease

Bovine Spongiform Encephalopathy - U.S. expands mad cow testing to cover 221,000 animals

Brain Cancer - Ritonavir treatment may benefit glioblastoma patients

Breast Cancer - Breast biopsy specimens can be evaluated with proteomic analysis

Breast Cancer - Overexpressed VEGF₁₂₁ improves oxygenation in certain breast tumors

Breast Cancer Prognosis - Thymidylate synthase mRNA predicts shorter survival in breast cancer

Cancer Therapy - Electric pulses show promise for healing or killing unhealthy cells

Cancer Therapy - XR5967 alters tumor cell invasion and angiogenesis in vitro

Cardiovascular Disease - AT1 receptor blocker increases efficacy of ACE inhibitors in murine DHF model

Cardiovascular Disease - Cardioprotective effects of scavenger receptor SR-BI clarified

Cardiovascular Disease - Role of ABCA1 in cholesterol metabolism reviewed

Cell Biology - Cells induced to "de-differentiate" back into stem cells

Cerebral Malaria - P-selectin plays key role in pathogenesis

Cervical Cancer - CDH1 and CDH13 methylation is a marker for more aggressive cervical cancer

Collaborations - LSBC, partner to manufacture and distribute plant-produced recombinant aprotinin

Complementary & Alternative Medicine - Grape seed extract demonstrates antiangiogenic potential in cultured cells

Creutzfeldt-Jakob Disease - Artificial prions created

Creutzfeldt-Jakob Disease - Protein-only prions show diverse repertoire

Dermatology - Nephrogenic fibrosing dermopathy linked to dysregulated matrix remodeling

Dermatology - Sphingosine has cytotoxic effects on growth of keloid fibroblasts

Developmental Biology - Researchers identify gene as essential for vascular smooth muscle development

Diabetes Pathogenesis - Low-protein diet alters gene expression in rat pancreatic islets

Diagnostics - Non-radioactive labeled hepatitis B virus probes are sensitive and inexpensive

Diagnostics - ProteinChip system receives medical device certification in China

Dioxin Antidote - Company announces in vivo proof of concept for Anticalins

Drug Delivery - Method produces uniform, self-assembled nanocells

Drug Development - Cell-penetrating, Rev-binding peptides can protect against HIV

Drug Development - Epidermal growth factor receptor inhibitors should stall cancer growth

Drug Development - Fibrinolytic, cardioprotective enzyme derived from fermented shrimp paste

Drug Development - Fungal derivatives show promise as HIV integrase inhibitors

Endocrinology - Lactating mammary glands respond to changes in extracellular calcium levels

Endocrinology - The tyrosine kinase inhibitor PTK787/ZK222584 staunches thyroid cancer growth

Environment & Health - Study suggests arsenic exposure alters estrogen signaling

Environmental Health - Radio frequency radiation affects protein kinase C activity in rat brains

Enzymology - Matrix metalloproteinase upregulation is fibronectin-dependent

Gastroenterology - Microarray distinguishes the molecular signatures of hepatocellular carcinomas

Gastroenterology - Tumor necrosis factor-alpha reduces D-fructose intestinal transport

Gene Deficiency - B cells develop and transcribe immunoglobulin despite Oct-1 deficiency

Gene Expression - Company launches Ovation Biotin System for Affymetrix GeneChip arrays

Gene Transfer - Arginine-rich peptides stabilize polyplexed DNA to improve transduction

Genetic Disorder - phe67leu mutation found in SRY gene in patient with 46,XY gonadal dysgenesis

Geriatrics - D-aspartyl endopeptidase scavenges noxious racemized proteins in aging

Glioblastoma - Tumor cell p53 function mediates endothelial cell radiosensitivity

HIV/AIDS Dementia - Soluble Fas levels in CSF correlate with HIV dementia severity

HIV/AIDS Proteins - Membrane-active gp41 regions identified

HIV/AIDS Therapy - Mitochondrial-to-nuclear DNA ratio may mark mitochondrial toxicity

Heart Attack - Plasma lipids augment post-infarction erythrocyte aggregation

Hematology - Fanconi anemia group C protein regulated through proteolytic modification

Hematology - Novel thioredoxin-related protein expressed in plasma cells identified

Hematology - P-selectin modulation involved in hemostasis

Heparin - Heparin binds to the laminin alpha 4 chain LG4 domain at a unique site

Hepatitis A Vaccine - Hepatitis A peptide covalently linked to liposomes

Hepatitis B Vaccine - Bacteriophage-mediated nucleic acid immunization offers benefits

Herpesvirus - Cells expressing herpesvirus entry mediator C are resistant to pseudorabies