Alzheimer Disease Pathogenesis
LDL receptor-related protein overexpression linked to memory deficits
Published in Proteomics Weekly, April 5th, 2004
"Amyloid-beta peptide (A-beta) is central to the pathogenesis of Alzheimer disease, and the low-density lipoprotein receptor-related protein (LRP) has been shown to alterA-beta metabolism in vitro. Here, we show that overexpression of a functional LRP minireceptor in the brain of PDAPP mice results in age-dependent increase of soluble brain A-beta, with no changes in A-beta plaque burden," scientists in the United States and Canada report.
"Importantly, soluble brain A-beta was found to be...
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Source: Proteomics Weekly (2004-04-05)
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