Creutzfeldt-Jakob Disease

Protein-only prions show diverse repertoire

Published in Proteomics Weekly, April 5th, 2004

Prions, the infectious agents responsible for conditions such as Creutzfeldt-Jakob disease, are made entirely of protein. What's more, different prion strains are generated by particles of the same protein folded into different conformations, two studies now show.

Chih-Yen King and Ruben Diaz-Avalos of Florida State University took a fragment of a protein called Sup35 that is responsible for prion propagation in yeast (Saccharomyces cerevisiae). They labeled it with fluorescent protein and introduced it into different groups of yeast cells, each containing a specific prion strain. The authors then re-isolated these fragments and used them as "seeds" to grow...

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Source: Proteomics Weekly (2004-04-05)

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