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Dermatology

Nephrogenic fibrosing dermopathy linked to dysregulated matrix remodeling

Published in Proteomics Weekly, April 5th, 2004

A variant of nephrogenic fibrosing dermopathy with osteoclast-like giant cells may be a syndrome of dysregulated matrix remodeling.

"Nephrogenic fibrosing dermopathy (NFD) is a disorder characterized by dramatic thickening and hardening of skin in the extremities and trunk, which occurs in individuals on dialysis for renal disease. The pathophysiology is unknown. Increased transforming growth factor-beta (TGF-beta) and collagen deposition have been reported in a small group of patients studied by Jimenez et al.," researchers in the United States report.

"We report two patients with NFD and osteoclast-like giant cells in the fibrotic dermis; one...

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