Immunology
CpG methylation of plasmid vectors circumvents immune response activation
Published in Proteomics Weekly, April 5th, 2004
According to a study from the United States, "gene therapy has the potential to cure inherited diseases if the delivered genes achieve long-term expression at therapeutic levels in the targeted tissues. Expression is commonly short-lived due to induction of cell-mediated immune responses to the gene therapy vehicle and/or the transgene product, which can be perceived as 'foreign' by the host's immune system. Plasmid expression vectors have been used to deliver genes."
"Bacterial DNA carries immunostimulatory sequences in the form of unmethylated CpG motifs, which induce an...
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Source: Proteomics Weekly (2004-04-05)
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