Proteomics Weekly

Alzheimer Disease - BACE 1 cleaves amyloid-beta precursor protein

Huntington Disease - Cytoplasmic aggregates block axonal transport in Huntington model

Insulin - MafA transcription factor responsible for insulin expression

Myotonic Dystrophy - Transgenic mice expressing DMPK 3'-UTR exhibit inhibition of myogenesis

Prion Disease - Variations in infectious protein determine prion strain differences

Allergy Medicine - Inhibition of SCF lowers cytokine release during allergic airway responses

Allergy Medicine - Ozone augments antigen-presenting activity in rats

Alzheimer Disease - Can curry protect against neurodegenerative diseases?

Alzheimer Disease - Glucose metabolism changes lead to tau hyperphosphorylation

Aneurysm - Intracranial aneurysms in Finnish families linked to chromosome 19q13.3

Atherosclerosis - Apolipoprotein A-I gene transfer helps the arteries of apo E-deficient mice

Atherosclerosis Pathogenesis - Information supports protective cytokine hypothesis of atherosclerosis

Autoimmune Diseases - Protein may help prevent autoimmune attacks

Bacterial Toxin - Small molecule inhibitors found active against anthrax lethal factor

Bacteriology - Overproduction of Lon protease inhibits translation in E. coli

Batten Disease - Motifs target Batten disease protein to lysosomes in neuronal cells

Bovine Spongiform Encephalopathy - Kansas leaders asks USDA for flexibility on downer cattle

Bovine Spongiform Encephalopathy - Mad cow testing issue divides cattle industry

Bovine Tuberculosis - USDA says Michigan progressing on eradication of bovine tuberculosis

Breast Cancer - Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo

Breast Cancer - Ring finger protein RNF11 important target for novel cancer therapies

Breast Cancer Prognosis - Urokinase-type plasminogen activator is prognostic in breast cancer

Breast Cancer Vaccine - NY-ESO-1 shows promise as antigen for breast cancer vaccine development

Cancer Gene Therapy - Fiber-mutant adenovirus vectors have antitumor activity

Cancer Vaccine - CD8+ T cells against Her-2/neu antigens possess antitumor activity

Cell Biology - Thrifty bacteria use just-in-time ordering

Cell Transduction - Intracellular MDA-7/IL-24 mediates activity in lung cancer cells

Colitis Risk Factor - Decay-accelerating factor deficiency increases colitis risk

Colon Cancer - Company licenses new colon cancer gene

Colon Cancer - Unlikely protein boosts metastatic colon cancer growth

Colorectal Cancer - Thymidylate synthase expression not linked to colon cancer phenotype

Complementary & Alternative Medicine - Wikyungtang herb inhibits proliferation of lung cancer cells in vitro

DNA Repair - UV-induced ATR activation requires replication stress

Diabetes Pathogenesis - Extrapancreatic insulin-producing cells found in multiple organs

Diabetes Pathogenesis - Muscarinic receptor type 3 linked to islet secretory responses

Diabetes Pathogenesis - Rosiglitazone prevents impairment of islets induced by fatty acids

Diagnostics - Monoclonal antibodies useful for FACS detection of intracellular Toxoplasma

Drug Development - N-terminally PEGylated interferon-beta yields improved pharmacology

Drug Discovery - Challenges of virtual screening for kinase targets demystified

Drug Mechanisms - Curcumin induces apoptosis via impairment of the ubiquitin-proteasome system

Drug Toxicity - Subchronic toxicity from enzymatically decomposed rutin not observed in rats

Endocrinology - Rise in fructose increases hepatic glucose-6-phosphatase mRNA

Endocrionology - High glucocorticoid levels reduce bone formation

Endotoxemia - Blood-cell derived TF influences endotoxin-induced coagulation, inflammation

Enzymology - Phosphatase Reg1p-Glc7p needed for fructose-phosphatase degradation

Enzymology - Protease nexin-1 inhibits apoptosis of adherent cells

Enzymology - Serine protease inhibitor gene cluster at 14q32.1 investigated

Enzymology - Serine/threonine kinase enriched in brain is involved in NGF signaling

Enzymology - Tryptophanyl-tRNA synthetase needs peptide insertions for angiostatic activity

Gastric Cancer - Insulin-like growth factor binding protein helps prevent gastric cancer

Gastroenterology - Pancreatic antimicrobial activity and protein release are nonparallel

Gastrointestinal Tumors - Telomerase inhibitor PinX1 not involved in gastrointestinal tract carcinoma

Gene Mapping - Consortium working toward link between genome sequence scaffold, human diseases

Genomics - Endostatin stalls angiogenesis with a complex network of control signals

Genomics - LCR promotes beta-globin transcription repression in committed cells

HIV/AIDS - Effect of HIV infection on NK cell inhibitory receptors clarified

HIV/AIDS Drug Resistance - HIV gp120 mutations linked to BMS-806 and #155 resistance identified

HIV/AIDS Proteomics - Actin filaments play role in intracellular transport of nascent HIV-1 proteins

HIV/AIDS Proteomics - Link between HIV core maturation and virus-cell fusion identified

HIV/AIDS Proteomics - Single amino acid of APOBEC3G controls species-specific interaction with Vif

HIV/AIDS Therapy - Metabolic effects of lopinavir-ritonavir regimens evaluated

HIV/AIDS Vaccine - Determining features of HIV neutralization phenotype identified

Hearing Research - Cochlear ablation in mice lacking SHP-1 results in neural cell death

Hematology - Differential proteome analysis of TRAP-activated platelets described

Hematology - Thrombospondin-1 internalization requires heparin sulfate proteoglycans

Hepatology - Mechanical massage enhances liver cell gene transfer in the mouse

Herpesvirus - HSV-1 Us3 protein kinase blocks apoptosis induced by Bcl-2 expression

Herpesvirus Vaccine - Gammaherpesvirus-68 mutant deficient for ORF73 has vaccine potential

Human T-cell Lymphotropic Virus - Structure of subunits of HTLV-1 envelope glycoproteins analyzed

Immunology -  Entamoeba histolytica L-arginase blocks NO-mediated macrophage activity

Immunology -  Herpesvirus saimiri Tip induces T-cell apoptosis

Immunology - B-1 cell numbers and immune responses increased in mice lacking APS

Immunology - Fas-mediated apoptosis underlies estrogen-induced thymic atrophy