Diabetes Pathogenesis

Rosiglitazone prevents impairment of islets induced by fatty acids

Published in Proteomics Weekly, May 10th, 2004

Rosiglitazone prevents the impairment of human islet function induced by fatty acids, which provides evidence for a role of PPAR gamma₂ in the modulation of insulin secretion.

According to a study from Italy, "Peroxisome proliferator-activated receptors (PPARs) are a subgroup of the superfamily of nuclear receptors, with three distinct main types: alpha, beta, and gamma (subdivided into gamma₁ and gamma₂ ). Recently, the presence of PPAR-gamma has been reported in human islets. Whether other PPAR types can be found in human islets, how islet PPAR-gamma mRNA expression is regulated by the metabolic milieu, their role in insulin...

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Source: Proteomics Weekly (2004-05-10)

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