Proteomics Weekly

Cleft Lip and Palate - Novel mutation of IRF6 gene found in family with Van der Woude syndrome

Inflammation - Mice deficient in Tir8 develop intestinal inflammation

Inflammatory Bowel Disease - Cathepsin D is upregulated in inflammatory bowel disease macrophages

Inner Ear - Vestibular defects in head-tilt mice result from mutations in Nox3

Mental Health - Cannabinoid CB1 receptor inverse agonist has antidepressant effects

AIDS/HIV Vaccine - Neutralizing antibodies against HIV-1 tat antigen characterized

Adenoviral Vector - The survivin promoter is tumor-specific in virus-mediated gene therapy

Adverse Drug Effects - Doxorubicin engenders paradoxical signals in the heart

Allergy - Unknown mechanism of action involved in expression of cytokines in mast cells

Alzheimer Disease - APP contributes to inflammatory condition in Alzheimer disease

Alzheimer Disease - Glutamate receptor upregulates amyloid precursor protein secretion

Alzheimer Disease - Rab6 membrane association dependent on cellular phosphorylation events

Analgesics - Opioid peptide with mu agonist/delta antagonist properties reported

Angiology - Neuropeptide Y is sympathetic modulator in saphenous vein biopsies

Anthrax - NERD is DNA processing-related domain in anthrax virulence plasmid

Anthrax Vaccine - Membranal polypeptides of Bacillus anthracis identified

Antibiotics - Novel inhibitors of bacterial RNA polymerase I characterized

Antidepressants - Inhibitors of cAMP phosphodiesterase possess antidepressant effects

Antimicrobials - Inhibitors target phosphorelay signal transduction systems of microbes

Arthritis - Staphylococcal protease does not affect outcome of infectious arthritis

Ataxia-Telangiectasia - Antioxidant corrects neurobehavioral defect in ataxia-telangiectasia

Bacillus - Site-directed mutagenesis of conserved residues in Bacillus reported

Bacteriology - Chemokines and cytokines expressed in Salmonella-infected chicken hatchlings

Bacteriology - Wisconsin chemists find a new chink in TB's armor

Basal Cell Carcinoma - Hedgehog-interacting protein prevents basal cell carcinoma

Bioengineering - A new recombinant polymer augments angiogenesis and other functions

Biotechnology - Native cell membranes deposited on biocompatible micropatterns

Bone Marrow - Marrow adipocytes lacking in hydroxysteroid dehydrogenase deficiency

Brain Development - Human frontal cortex development depends on G protein-coupled receptor

Breast Cancer - Cyclin-dependent kinase 2 activated by cyclin E in breast cancer cells

Breast Cancer - Cytological and histological diagnostic markers compared

Breast Cancer - Nuclear receptor LRH-1 regulates aromatase expression in adipose tissue

Breast Cancer - Protective role of fibulin-1 elucidated

Breast Cancer - Studies describe how mutations affect BRCA1 function

Breast Cancer Therapy - Enzyme inhibitor enhances the work of breast cancer adjuvant endocrine therapy

Breast Cancer Therapy - Gefitinib and trastuzumab show promise for treatment of metastatic breast cancer

Burkholderia -  Burkholderia pseudomallei collagenase identified in Escherichia coli

Business & Finance - Drug-discovery company reports on portfolio, announces lower first quarter net losses

Cachexia - Melanocortin 4 receptor antagonist reduces tumor-induced weight loss

Cancer Therapy - Radiolabeled peptides rise to the challenge in the face of cancer

Cancer Vaccine - Plasmids costimulate DNA vaccine against carcinoembryonic antigen

Cardiology - EF-hand couples intracellular calcium to cardiac excitability

Cardiology - Novel hLAMP-1 clones should facilitate study

Cell Biology - Scientists publish novel findings about neovessel formation

Cell Signaling - MMP3 involved in control of synaptic structure at the neuromuscular junction

Cell biology - Thiol depletion aids bax-induced programmed cell death in lung cancer cells

Central Nervous System - Human CD34+ cells differentiate into microglia

Charcot-Marie-Tooth Disease - Novel mutation found in MPZ gene in Charcot-Marie-Tooth patient

Charcot-Marie-Tooth disease - Heat shock proteins discovered to cause neurological disease

Chorea-Acanthocytosis - New family of chorea-acanthocytosis reported

Citrobacter Rodentium - Novel C. rodentium type III secreted proteins reduce colon hyperplasia

Cloning - Company provides two NIH agencies with open access to cloning technologies

Cloning - Splicing variants of novel Rnd2 effector Rapostlin induces neurite branching

Colon Cancer - Valproic acid modulates the synthesis of angiogenic proteins in cancer cells

Cytomegalovirus Vaccine - Cytomegalovirus glycoprotein elicits antibody response in macaques

DFNA9 Syndrome - American genetic abnormality also discovered in The Netherlands

Dermatology - Undifferentiated Merkel cells may be a forerunner of Merkel cell carcinoma

Diabetes Genomics and Genetics - Deletion in mitochondrial DNA found in patient with diabetes

Diabetes Pathogenesis - Cytokine gene expression in diabetes pathogenesis discussed

Diabetes Pathogenesis - Mammalian target of rapamycin regulates IRS-1 serine phosphorylation

Diabetes Pathogenesis - PPAR-alpha deficiency does not alter insulin sensitivity in mice

Diabetes Pathogenesis - c-Maf and MafA activate insulin gene expression in beta-cells

Diabetes Therapy - Palmitate-derivatized GLP-1 analogues exhibit antihyperglycemic action

Dialysis - Serum growth factor activity characterized in hemodialysis patients

Diet and Nutrition - n-3 Polyunsaturated fatty acids may prevent colon cancer

Digestive System Tumors - GW112 is a novel antiapoptotic protein

Drug Addiction - Dopamine signaling enhanced in brain of mice lacking dopamine receptor

Drug Delivery - Company initiates intranasal parathyroid hormone clinical development

Drug Delivery - Hydrodynamic injection accomplishes transduction through hydroporation

Drug Development - Novel splice variant mRNAs from known drug target genes cloned

Drug Development - Property-based sequence motifs used to determine protein structures

Drug Discovery - Grant to enable study of crystallization processes of membrane-associated proteins

Drug Resistance - Gleevec reverses cellular resistance to topotecan and SN-38

Encephalomyelitis - Nitric oxide plays protective role in murine encephalomyelitis model

Endocrinology - Annexin II is gene involved in insulin-induced glucose transport

Endocrinology - Endogenous human prolactin amplifies the effects of estrogen on breast cancer

Endocrinology - Expression of thyroid hormone receptor isoforms in the oligodendrocyte lineage

Endocrinology - Glucose and alcohol exert different effects on reactive oxygen species

Endocrinology - Mechanism of glycoprotein hormone receptor activity discussed

Endocrinology - Method to determine incretin hormone levels in human plasma developed

Endocrinology - Phosphorylated proteins in human pituitary characterized

Endocrinology - Phosphorylation site in elongation factor 2 kinase modulates activity

Endocrinology - Regulation of luteinizing hormone receptor expression reviewed

Endocrinology - Stomach can be considered an endocrine organ

Endocrinology - Translational repression mediated by the GM-CSF AU-rich element

Endocrinology - Vasopressin release reduced in ovariectomy restored by oestradiol replacement

Environmental Health - CYP1A2 is not required for dioxin-induced immunosuppression

Enzymology - Human and rat glucokinase regulatory proteins compared

Enzymology - Hyaluronan-binding protease stops cytokine-driven endothelial cell growth

Exercise - Aerobic exercise may attenuate age-related decline in protein synthesis

Finance - Genomics company reports "disappointing" first quarter results

Finance - Revenue from NMP22 products up 157% over the same period in 2003

Food-Borne Illness - Botulinum toxin structure offers clues for vaccines/treatments

Food-Borne Illness - Gene probes for quantifying Vibrio in crabmeat evaluated

Gene Profiling - Human liver cancer cells differentiate during confluence

Genetic Disorder - Gating of polycystin ion channel signaling in neurons reviewed

Genomics -  T. brucei genes encode functional PMCAs essential for Ca²⁺ homeostasis

Genomics - Beta-catenin regulates the gene of unique novel matrix metalloproteinase-26

Genomics - Chromatin structure of ribosomal DNA causes genome instability

Gingivitis - Gingipain adhesin mediates Porphyromonas gingivalis adherence

Graves' Disease - Dynamics of thyrotropin receptor antibodies in Graves' disease studied

HIV/AIDS - V82F/184V mutation decreases binding affinity of HIV-1 protease inhibitors

HIV/AIDS Research - RH116 differentially regulates cell growth, death and HIV-1 replication

HIV/AIDS Treatment - NRTIs D- and L-D4FC-TP promising as potential anti-HIV-1 drugs

Head and Neck Cancer - Heat shock protein 27 predicts neoplastic changes in Barrett esophagus

Health - Application of genomics and proteomics to neurosciences outlined

Hearing Disorder - Molecular genetics of hereditary deafness reviewed

Heart Disease Risk Factor - Profilin acts to mediate diabetic endothelial cell dysfunction

Heart Transplantation - Anti-TIRC7 mAb prevents graft rejection in mice

Helicobacter - Protein kinase C activation by H. pylori limits IL-8 production

Hematology - Some para-sulfonato-calix-[n]-arenes possess hemolytic properties

Hemorrhagic Fever - Crimean-Congo hemorrhagic fever virus genome L RNA segment sequenced

Hepatology - COX-2 correlates with VEGF and angiogenesis in hepatitis B-linked cancer

Herpesvirus - Murine herpesvirus-68 ORF73 critical for latency establishment and maintenance

Hypercholesterolemia - L-Arginine inhibits endothelial dysfunction in hypercholesterolemia

Hypoglycemia - A₁ adenosine receptors mediate hypoglycemia-induced neuronal injury

Immunodeficiency - Allogeneic bone marrow transplant restores growth in gamma-SCID patient

Immunology - Astrocytes have neuroprotective role during inflammation