Alzheimer Disease
Glutamate receptor upregulates amyloid precursor protein secretion
Published in Proteomics Weekly, May 31st, 2004
According to recent research from England, "Using the novel rat retinal-vitreal model we have investigated the effect of metabotropic glutamate receptor activation on amyloid precursor protein (APP) metabolism. The release of low molecular weight fragments of APP, at 15-23 kDa in particular, was markedly upregulated by the metabotropic glutamate receptor agonist (1S,3R)-1-amino-1,3-cyclopentane dicarboxylic acid [(1S,3R)ACPD] in a concentration- and time-dependent manner, and this response was blocked by the receptor antagonist...
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Source: Proteomics Weekly (2004-05-31)
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