Neuroscience
Cerebral cytokine-induced inflammation reduced by alpha-tocopherol
Published in Proteomics Weekly, May 31st, 2004
Researchers in the United States conducted a study "to determine if alpha-tocopherol - a reactive oxygen species (ROS) scavenging agent - inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain.
"LPS increased intracellular peroxides and IL-6 in a dose-dependent fashion in primary microglia. The LPS-induced increase in ROS and IL-6 was reduced by pretreatment of alpha-tocopherol," reported J.P. Godbout and coauthors at the University of Illinois at Urbana-Champaign.
"lntraperitoneal...
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Source: Proteomics Weekly (2004-05-31)
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