Inflammation
Mice deficient in Tir8 develop intestinal inflammation
Published in Proteomics Weekly, May 31st, 2004
"TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Here we report that Tir8 has a unique pattern of expression, which includes mucosal tissues and dendritic cells (DC). Tir8-deficient DC showed increased cytokine production in response to TLR agonists (lipopolysaccharide, CpG oligodeoxynucleotides)," researchers in Italy report.
"Tir8-deficient mice had normal susceptibility to systemic...
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Source: Proteomics Weekly (2004-05-31)
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