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Mental Health

Cannabinoid CB1 receptor inverse agonist has antidepressant effects

Published in Proteomics Weekly, May 31st, 2004

The cannabinoid CB1 receptor inverse agonist AM251 exhibited antidepressant-like and anorectic effects in mice.

"Psychopathological disorders, and depression in particular, are strongly linked to eating attitude in obese patients. The identification of cannabinoid CB1 receptors (CB1Rs) in areas of the central nervous system (CNS) that have been implicated in regulation of mood and food intake suggests that these receptors may mediate such a behavioral link. The goal of this study was to evaluate CB1R modulation of antidepressant-like effects and food intake," investigators in the United States report.

"For this purpose, 129/SVE and C57BL/6 male mice...

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