AIDS/HIV Vaccine
Neutralizing antibodies against HIV-1 tat antigen characterized
Published in Proteomics Weekly, May 31st, 2004
According to a study from France, "The human immunodeficiency virus Tat regulatory protein is essential for virus replication and pathogenesis. From human peripheral blood mononuclear cells of three Tat toxoid-immunized volunteers, we isolated five Tat-specific human monoclonal antibodies (HMAbs): two full-length immunoglobulin G (IgG) antibodies and three single-chain fragment-variable (scFv) antibodies. The two IgGs were mapped to distinct epitopes within the basic region of Tat, and the three scFvs were mapped to the N-terminal domain of...
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Source: Proteomics Weekly (2004-05-31)
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