Adenoviral Vector
The survivin promoter is tumor-specific in virus-mediated gene therapy
Published in Proteomics Weekly, May 31st, 2004
"It has been demonstrated that survivin, a novel member of the inhibitor of apoptosis (IAP) protein family, is expressed in human cancers but is undetectable in normal differentiated tissues. We employed a recombinant adenoviral vector (reAdGL3BSurvivin) in which a tumor-specific survivin promoter and a luciferase reporter gene were inserted into the E1-deleted region of adenovirus vector. Luciferase activity was measured in both multiple tumor cell lines and two primary melanoma cells infected with reAdGL3BSurvivin," researchers in the United States report.
"Human fibroblast and...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Proteomics Weekly
Source: Proteomics Weekly (2004-05-31)
More Articles from Proteomics Weekly
- Cleft Lip and Palate
Novel mutation of IRF6 gene found in family with Van der Woude syndrome - Inflammation
Mice deficient in Tir8 develop intestinal inflammation - Inflammatory Bowel Disease
Cathepsin D is upregulated in inflammatory bowel disease macrophages - Inner Ear
Vestibular defects in head-tilt mice result from mutations in Nox3 - Mental Health
Cannabinoid CB1 receptor inverse agonist has antidepressant effects - AIDS/HIV Vaccine
Neutralizing antibodies against HIV-1 tat antigen characterized - More from this issue of Proteomics Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
