Proteomics Weekly

Protein Kinase C - PKB/Akt activity, Ser⁴⁷³ phosphorylation regulated by PKCalpha

Proteomics - 3D structure of pre-catalytic spliceosomal complex B determined

Proteomics - Improved method devised for synthesis of peptides with free C termini

Proteomics - Novel markers identified for alveolar epithelial cells

Proteomics - ShcA isoform regulates MAPKAP kinase 2 activity

Acute Pancreatitis - Endothelial nitric oxide synthase is protective in mice

Adiposity - Serum haptoglobin is novel marker of adiposity in humans

Allergy Medicine - Toll-like receptors may be good vaccine candidates in allergic disease

Alzheimer Disease - A role for Nogo in neurodegenerative disease?

Alzheimer Disease - First visualization of "tangles" in frontotemporal dementia described

Alzheimer Disease - Folding of Alzheimer core PHF subunit characterized

Alzheimer Disease - Researchers find peptide biomarkers effective in early diagnosis of Alzheimer

Alzheimer Disease - Results on biomarkers for early diagnosis of Alzheimer Disease announced

Angiogenesis - Cathepsin cysteine proteases effect invasive growth, angiogenesis

Antiretroviral Therapy - Microglia-expressed MRPs may restrict permeation of antiretroviral drugs

Arthritis - Antirheumatic METOLATE tablets launched in Japan

Autism - Immune abnormalities associated with autism

Autoimmune Disease - FasL-overexpressing dendritic cells purge activated T cells

Bacteriology - Clip-and-link activity of repeat in gram-negative pathogen RTX proteins found

Biomarker Assays - Company launches ProteinChip System, Series 4000

Breast Cancer Vaccine - Dendritic cell vaccine safe in patients with advanced breast cancer

Business Update - Morphotek, Inc., announces research and commercialization agreement

Cancer Genetics - Missense mutations frequently perturb BRCA-1 protein

Cancer Metastasis - hsp90 alpha has essential extracellular role in cancer cell invasiveness

Cancer Therapy - Biotech company confirms plans to produce Multiferon at Swedish facility

Cancer Therapy - Celera, Seattle Genetics, to co-develop targeted antibody therapies for cancer

Cancer Therapy - Study suggests cysteine cathepsins offer cancer treatment opportunities

Cancer Vaccine - Anti-idiotypic scFv used as surrogate tumor antigen characterized

Cancer Vaccine - Antitumor neoglycopeptide vaccine with Tn antigen synthesized

Cardiopulmonary Disease - Air pollution increases vasoconstriction in the lungs of rats

Cardiovascular Disease - Go 6983 attenuates myocardial ischemia/reperfusion injury

Cardiovascular Disease - Recombinant P-selectin glycoprotein ligand-1 prevents in-stent restenosis

Cataracts - Oxidative stress up-regulates chloride channel during cataractogenesis

Cell Biology - One taste of growth protein and nerve cells want more

Cell Biology - Protein key to trafficking in nerve terminals

Chemokine Receptor - Low pH not required for RANTES or MIP-1beta dissociation from CCR5

Collaborations - Genome-wide line of RNA assays for gene silencing measurement launched

Coronavirus - Novel peptides inhibit SARS coronavirus

Creutzfeldt-Jakob Disease - In vitro test systems compared

Cystic Fibrosis - Domain mimic may help correct protein trafficking defect in CF epithelia

DNA Analysis - Quadruplex regulates expression of c-Myc oncogene, adopts parallel-loop isomers

DNA Repair - FANCD2 has direct interaction with BRCA2 in DNA damage response pathways

Dendritic Cell Vaccine - Dendritic cell vaccine enhances T cell responses in gastric cancer

Dermatology - Dermal effects of UVA irradiation determined in vivo

Dermatology - Effects of tenascin-X deficiency elucidated

Diabetes Complications - Diabetes alters response to bacteria by enhancing fibroblast apoptosis

Diabetes Genomics & Genetics - PPAR-gamma coactivator-1 variant not associated with diabetes-related traits

Diabetes Genomics & Genetics - Type 1 diabetes susceptibility locus found on chromosome 5q11-q13

Diabetes Pathogenesis - Glucocorticoid receptor inactivation in hepatocytes leads to hypoglycemia

Diabetes Pathogenesis - Insulin and muscle contraction activate mitogen-activated protein kinase

Diabetes Pathogenesis - Protein kinase cascade plays role in glucose upregulation of insulin gene

Diabetes Pathogenesis - Tanis/SelS mRNA expression up-regulated after insulin infusion in diabetes

Diabetes Therapy - Metformin inhibits tyrosine phosphatase to stimulate tyrosine kinase

Drug Delivery - DelSite inks vaccine research agreement and expands facilities

Drug Development - Hepatic CYP isoforms inhibited by mGluR5 antagonists

Drug Development - Phage display-derived peptides provide therapeutic alternatives to antibodies

Endocrinology - Cervical ripening associated with decreased prostaglandin degradation

Endocrinology - Progesterone and glucocorticoids can differentially regulate relaxin genes

Endometrial Cancer - Protein expression profiling malignancies reveals new tumor marker

Environmental Health - Genomic effects of JP-8 jet fuel determined

Evolutionary Biology - Study finds anti-HIV protein evolved millions of years before emergence of AIDS

Finance - Antidepressant maker reports fiscal Q1 earnings of $.60 per share

Gastric Cancer - DOG1 ubiquitously expressed in gastrointestinal stromal tumors

Gastroenterology - Proteins expressed by H. pylori-infected gastric epithelial cells identified

Gene Profiling - Proteomics company acquires rights to DNA modification chemistry patents

Genetics - Model for imaging gene expression by trans-splicing described

Genomics - Company identifies 12,723 A to I RNA editing sites in the human transcriptome

Genomics - U.S. National Institutes of Health expands relationship with genetics company

Genomics and Genetics - Genomic and metabolic effects of fatty liver disease clarified

Genomics and Genetics - Transcription factor AP-2alpha plays key role in trophoblast differentiation

Glaucoma - Effect of hydrostatic pressure on ONH astrocyte gene expression determined

Gynecology - G(i)-Ras-MEKK1 signaling pathway mediates LPA-stimulated cancer-cell migration