Ovarian Cancer

Novel cysteine protease cleaves ubiquitin in human ovarian cancer cells

Published in Proteomics Weekly, September 20th, 2004

A novel cystein protease, HeLa DUB-1, cleaves ubiquitin in human ovarian cancer cells, according to a study from South Korea.

"The regulation of ubiquitin-mediated protein degradation is becoming important for a number of cellular processes," said M.S. Kim and colleagues at Pochon CHA University's General Hospital in Seoul.

Kim's group isolated human HeLa DUB-1 cDNA, encoding a novel de-ubiquitinating enzyme from ovarian cancer cells.

"It has 1,647 bp nucleotides and encodes a 548 amino acid polypeptide with the molecular weight of approximately 61 kDa. It contains the highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains...

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Source: Proteomics Weekly (2004-09-20)

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