Prion Disease

Multiple antigenic peptides promote anti-prion antibodies

Published in Proteomics Weekly, September 20th, 2004

Multiple antigenic peptides facilitate generation of anti-prion antibodies.

According to a study from England, "Recent reports have demonstrated the ability of anti-prion antibodies to inhibit PrP^Sc propagation. Due to the relatively poor immunogenic properties of both PrP^c and PrP^Sc, the generation of anti-prion antibodies still causes a significant problem in the development of immunotherapeutic strategies. This study examines the potential of multiple antigenic peptides (MAPs) to raise an antibody response to prion derived sequences in mice."

"The MAP was constructed of a four-spiked ring," said J. Bainbridge and...

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Source: Proteomics Weekly (2004-09-20)

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