Published in Proteomics Weekly, September 20th, 2004
According to recent research published in the journal Analytical Chemistry, "an ultrasensitive nucleic acid biosensor for direct detection of genes in mRNA extracted from animal tissues is described. It is based on amperometric detection of a target gene by forming an mRNA/redox polymer bilayer on a gold electrode. The mRNA was directly labeled with cisplatin-biotin conjugates through coordinative bonds with purine bases in the mRNA molecules."
"A subsequent binding of glucose oxidase-avidin conjugates to the labeled mRNA and the introduction of a...
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