RNA Virus

Calicivirus 3C-like proteinase inhibits cellular translation by PABP cleavage

Published in Proteomics Weekly, October 4th, 2004

Calicivirus 3C-like proteinase inhibits cellular translation by poly(A)-binding protein cleavage.

According to recent research from the United States, "Caliciviruses are single-stranded RNA viruses that cause a wide range of diseases in both humans and animals, but little is known about the regulation of cellular translation during infection.

"We used two distinct calicivirus strains, MD145-12 (genus Norovirus) and feline calicivirus (FCV) (genus Vesivirus), to investigate potential strategies used by the caliciviruses to inhibit cellular translation."

"Recombinant 3C-like proteinases (r3CL^pro) from...

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Source: Proteomics Weekly (2004-10-04)

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