Cholesterol Homeostasis
NPC1L1 may be useful for treating hypercholesterolemia and sitosterolemia
Published in Proteomics Weekly, October 4th, 2004
"Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that is critical for intestinal cholesterol absorption. The uptake of intestinal phytosterols and cholesterol into absorptive enterocytes in the intestine is not fully defined on a molecular level, and the role of NPC1L1 in maintaining whole body cholesterol homeostasis is not known," scientists writing in the Journal of Biological Chemistry report.
"NPC1L1 null mice had substantially reduced intestinal uptake of...
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Source: Proteomics Weekly (2004-10-04)
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