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Diagnostics

Direct protein microarray detection strategies reviewed

Published in Proteomics Weekly, October 4th, 2004

Scientists review direct protein microarray detection strategies in a recent issue of the Journal of Immunological Methods.

"Protein microarrays are being utilized for functional proteomic analysis, providing information not obtainable by gene arrays. Microarray technology is applicable for studying protein-protein, protein-ligand, kinase activity, and posuranslational modifications of proteins. A precise and sensitive protein microarray, the direct detection or reverse-phase microarray, has been applied to ongoing clinical trials at the National Cancer Institute for studying phosphorylation events in EGF-receptor-mediated cell signaling pathways," investigators...

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