Geriatrics

Prion protein may be involved in early-onset Alzheimer disease

Published in Proteomics Weekly, October 4th, 2004

Prion protein may be involved in early-onset Alzheimer disease.

According to a study from Germany, "the authors investigated the prion protein gene (PRNP) Met(129)Val polymorphism in 1393 subjects including 482 patients with Alzheimer disease (AD) and two independent control groups."

"In patients, PRNP Met homozygosity conferred increasing risk with decreasing age at onset (onset: 61 to 70 years, n=151, p=0.02, odds ratio [OR]=1.72, 95% CI=1.2 to 2.53; onset: {{<=}}60 years, n=138, p=0.013, OR=1.92, 95% CI=1.31 to 2.87), whereas no association was obtained in patients with onset at older than 70 years," reported M. Riemenschneider and colleagues,...

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Source: Proteomics Weekly (2004-10-04)

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