Interleukin

Expanded family of class II cytokines share IL-10 receptor-2 (IL-10R2) chain

Published in Proteomics Weekly, October 4th, 2004

Scientists describe the expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain in a recent issue of the Journal of Leukocyte Biology.

"Several novel interleukin (IL)-10-related cytokines have recently been discovered. These include IL-22, IL-26, and the interferon-lambda (IFN-lambda) proteins IFN-lambda1 (IL-29), IFN-lambda2 (IL-28A), and IFN-lambda3 (IL-28B). The ligand-binding chains for IL-22, IL-26, and IFN-lambda are distinct from that used by IL-10; however, all of these cytokines use a common second chain, IL-10 receptor-2 (IL-10R2; CRF2-4), to assemble their active receptor complexes. Thus, IL-10R2 is a shared component in...

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Source: Proteomics Weekly (2004-10-04)

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