Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . October 18th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
HIV/AIDS Research - Packaging HIV vectors with FIV is viable alternative to HIV structural proteins
Head and Neck Cancer - Amyloid precursor protein is a prognostic marker for oral carcinogenesis
Lung Carcinoma - Peroxiredoxins seem to influence lung cancer progression
Proteomics - Novel assay facilitates analysis of NK cell microsomal proteins
Receptor Studies - Green-fluorescent-protein-based assay characterizes G-protein-coupled receptors
Alcoholic Cardiomyopathy - Review summarizes the role of acetaldehyde in alcoholic cardiomyopathy
Alzheimer Disease - Human blood sample bank launches Alzheimer disease genetic collection
Alzheimer Disease - Tyrosine gated electron transfer toxic mechanism key of Alzheimer beta-amyloid
Alzheimer Disease - Zinc-binding agonists affect recognition of beta-amyloid epitopes
Angiology - Novel culture system simulates vascular microenvironment
Antiviral Therapy - The p38 signaling pathway influences the response of hepatitis C to interferon
Bladder Cancer - Health Canada approves marketing of diagnostic test for bladder cancer
Body Composition - Polymorphism in glucocorticoid receptor gene linked to good body composition
Breast Cancer - CCND1 overexpression common in male patients
Breast Cancer - Genetic markers of breast tumor estrogen/progesterone receptors identified
Breast Cancer - NMP66 breast cancer detection results presented at conference
Breast Cancer - Phosphorylation of Y845 mediates binding to the mitochondrial protein
Breast Cancer - Research agreement signed to ID early biomarkers for breast cancer
Business Update - Invitrogen Corporation announces licensing agreements
Cancer Genetics - Janus kinase 2 modulation in ovarian cancer cells may depend on p53
Cancer Therapy - Effects of HsEg5 inhibitor monastrol on tumor cells characterized
Cancer Vaccine - HSP70 expression in apoptotic cells correlates with antitumor efficacy
Cancer Vaccine - Heat shock protein tumor vaccine enhances immune responses
Cancer Vaccine - Poor immunogenicity of tumor antigen due to peptide-MHC-I instability
Cardiac Hypertrophy - Calcineurin-inhibitory strategies may lead to therapeutic approaches
Cardiac Hypertrophy - Signaling pathways have been implicated in cardiac hypertrophy
Cardiology - Carvedilol decreased neurohumoral activation and symptoms
Cardiology - Corin requires frizzled 1 domain and LDLR repeats 1-4 to recognize pro-ANP
Cardiology - Data highlight a mechanism for survival advantage in cardiac fibroblasts
Cardiology - NCX is regulated by Ca2+ during excitation-contraction coupling
Cardiology - Study demonstrates the expression of BNP the rat heart during growth
Cardiology - Study identifies possible gender-related factors in cardiac function
Cardiomyopathy - Calcineurin-NFAT and MAPK signaling pathways are interdependent
Cell Biology - ATF4 is translationally regulated by hypoxic stress
Cell Biology - GMAP-210 activity required for Golgi ribbon formation
Cell Biology - Molecular motor implicated in tissue remodeling
Cell Biology - NOBOX gene expression is crucial to postnatal follicle formation
Chemoresistance - Upregulation of BH3-only protein circumvents melanoma drug resistance
Chemotherapy - Scopadulciol-related molecules are weak mediators of cancer gene therapy
Childhood Obesity - Adiponectin level increases after weight loss in obese children
Colorectal Cancer - Acne-like rash linked to effectiveness of new targeted cancer treatment
Creutzfeldt-Jakob Disease - Causal link behind BSE and Creutzfeldt-Jakob disease has scientific basis
Cytomegalovirus Vaccine - Cytomegalovirus immune evasion proteins do not prevent T-cell response
DNA Research - Solid-phase preparation of DNA oligonucleotides described
DNA Research - Suppression of MCM10 and TopBP1 involved in UV-induced DNA damage
Dengue Virus Vaccine - Homotypic interaction domain of core protein of dengue virus identified
Diabetes Pathogenesis - Mice expressing TNDM locus have impaired glucose homeostasis
Diabetes Risk Factor - Type 1 diabetes risk defined by leukocyte antigen class II genotype
Diabetes Therapy - Glucocorticoid antagonists offer therapy option for type 2 diabetes
Diabetic Retinopathy - Glutamate receptor expression in retina diabetic rats examined
Diagnostic Imaging - Positron emission tomography grants a noninvasive look at transgene activity
Diagnostics - Buccal cells from mouthwash are a source of mRNA for molecular analysis
Diet and Nutrition - High-fat diet affects protein expression in muscle, adipose tissue, and liver
Drug Delivery - Phase III trials for Micropump formulation of a GlaxoSmithKline product begin
Drug Development - Plasmodium vivax hexose transporter characterized
Drug Development - Companies collaborate to develop, market genomic purification applications
Drug Development - Flavin-dependent thymidylate synthase activity characterized
Drug Development - HTG's gene-expression technology to support company's pharmaceutical research
Drug Development - LC/MALDI assay suitable for membrane proteome analysis
Drug Discovery - Biopharmaceutical company completes second performance milestone
Drug Discovery - Inexpensive thermal shift assay developed
Drug Discovery - Study of application of TRAP drug discovery technology published
Encephalomyelitis - Amino acid copolymers amerliorate encephalomyelitis
Environmental Toxins - Cigarette smoke causes breaks in DNA and defects to a cell's chromosomes
Environmental Toxins - Genetic mutations linked to the practice of burning coal in homes in China
Enzymology - Macrophages generate cytokines that stimulate breast cancer invasion
Enzymology - The hepatitis C virus NS5B C-21 domain has multifunctional properties
Exercise - Exercise normalizes overexpression of TNF-alpha in knockout mice
Gene Inhibition - Synthetic curcumin analogs curtail genes related to angiogenesis
Genetics - Researchers find soybean plant that lacks allergy-causing protein
Genomics - DNA sequencing software developer releases updates
Genomics - Genome company awarded National Human Genome Research Institute grant
Genomics - Sprouty1 may serve as an intrinsic mediator governing ventricular remodeling
Genomics and Genetics - Novel potentially defective CYP2C9 alleles identified
HIV/AIDS Research - ERK-2 regulates viral assembly and release by phosphorylating HIV-1 p6(Gag)
HIV/AIDS Research - HIV mRNA nuclear export elements regulate protein function and virion assembly
HIV/AIDS Therapy - Scientists successfully target key HIV protein
Head and Neck Cancer - Nitric oxide accelerates regression in head and neck cancer
Heart Failure Management - Reviews describes current recommendations for anticoagulation
Hematology - Age and genetics are among factors that influence TGF-beta2 activity
Hematology - Heme triggers the nuclear export of Bach in order to regulate gene expression
Hepatology - CYP3A promotes endotoxemic liver injury through oxidative stress
Hepatology - Main cytochrome P450 enzymes involved in safrole 1'-hydroxylation identified
Human Papillomavirus - Effects of HPV-18 proteins on keratinocyte gene expression determined
Hypertension - Angiotensinogen mRNA-stabilizing protein blockade lowers rodent blood pressure
Immunology - Novel mAbs used to elucidate T-cell RANKL expression
Immunology - Trafficking of anti-complement receptor antibody investigated
Infectious Disease - Leishmania glycosomal protein import elucidated
Infectious Disease - Immunological effects of Rho GTPase degradation by CNF1 clarified
Influenza Virus - Active NF-kappa B signaling is prerequisite for influenza infection
Information Technology - Automation technology launched for genomics, proteomics labs
Information Technology - Web-based software for analysis, reporting on raw DNA microarrays available
JC Virus - JC virus agnoprotein inhibits DNA repair after DNA damage
Kaposi Sarcoma-Associated Herpesvirus - KSHV ORF57 protein interacts with REF protein and acts as RNA export factor
Leptin Studies - Leptin regulates hypothalamic alpha-melanocyte-stimulating hormone
Leptin Studies - Role of leptin in farm animals reviewed
Leukemia - Evidence builds for potential new cancer drug target
Lipid Studies - C/EBP gene replacement stimulates mitochondrial biogenesis in fat cells
Lipid Studies - Interleukin-15 directly regulates lipolysis in primary pig adipocytes
Lung Cancer - Drug exposure may enhance in vitro invasiveness of lung cancer cell line
Lung Cancer - Genetic markers of heightened NSCLC metastasis risk identified
Lung Cancer Vaccine - Peptides eliciting multiple responses in lung cancer identified
Melanoma Vaccine - Immune responses to peptide epitope in melanoma patients described
Metastasis - Molecular switch found that allows cancer cells to become mobile
Microencapsulation - pH-triggered microparticles for peptide vaccination developed
Migraine Headache - Compound has been found to be efficacious in relief of acute attacks of migraine
Molecular Biology - VEGF is a selective Down syndrome critical region I gene expression activator
Myocardial Infarction - No difference in results between enzyme inhibitors and receptor blockers
Neuroscience - Mechanisms of synaptic regulation by BDNF elucidated
Neuroscience - Tissue plasminogen activator expression characterized in human CNS
Obesity Pathogenesis - Inactivation of mutated melanocortin receptor linked to obesity
Obesity Pathogenesis - JIP1 scaffold protein essential for JNK activation in adipose tissue
Obesity Pathogenesis - Role of arachidonate cascade during changes in adipocyte life cycle described
Obesity Surgery - Inflammatory mediators normalize with weight loss in morbidly obese patients
Obesity Therapy - Fasting-induced adipose factor increased by fenofibrate treatment
Obesity and Diabetes - Adipocytes of obese subjects exhibit impaired activation of protein kinase C
Obesity and Diabetes - Chronic hyper-resistinemia results in abnormal glucose homeostasis
Obstetrics - Beta2 -agonist treatment enhances OTR mRNA expression in pregnant rats
Oncogenesis - Angiogenic restraint is lost as myeloma progresses
Oncology - Midkine promoter-driven gene therapy strikes down immortalized and tumor cells
Ophthalmology - Researchers identify "light meter" that controls pupil constriction
Ovarian Cancer - Gene amplification is one mechanism for hK6 overexpression in ovarian cancer
Parkinson Disease - Discovery of gene-expression changes leads to advancement in Parkinson research
Patents - Companies win patents supporting Alzheimer disease immunotherapy treatments
Patents - Company awarded patent on human P2Y4 receptor
Patents - Genomics company receives international patents
Personnel - Biopharm company names new VPs of business development, intellectual property
Personnel - Biopharmaceutical company CFO retires, successor named
Physical Activity - Exercise increases anti-oxidation in liver of obese Zucker rats
Physiology - Neuropeptide Y antagonism lowers reflex cutaneous vasoconstriction
Product Licensing - Corgentech licenses peptide-delivery system to use with TF Decoys
Prostate Cancer - Cottonseed drug is cancer treatment booster - patient trials now planned
Prostate Cancer - Trial to assess if Zyflamend prevents prostate cancer
Protein Regulation - Variations in poly(A)-binding protein-interacting protein 2 sway angiogenesis
Protein Signaling - Structural differences identified in transmembrane of mouse, human NKG2D
Proteomics - Apo E has isoprotein-specific effects on many biological processes and diseases
Proteomics - Foxo1 is an essential element of vascular development
Proteomics - Function of S. cerevisiae Yaf9p protein clarified
Proteomics - HMGA1-mediated gene regulation is tissue-specific
Proteomics - Microenvironment has a strong bearing on the activity of syndecan-1
Proteomics - Neuroglycan C is a member of the neuregulin family
Proteomics - Photo-CIDNP NMR methods for protein fold imaging reviewed
Proteomics - Platelet factor 4 uses several avenues for angiogenesis suppression
Pulmonary Hypertension - Endothelin ETA receptor antagonist reverses pulmonary hypertension
Receptors - Review focuses on interaction between beta-AR and OPR in the heart
Rectal Cancer - Immunohistochemical markers of poor prognosis identified
Reproductive Medicine - Sperm-specific enolase characterized
Respiratory Distress - Cytokine release after esophagus resection suggests subclinical lung injury
Respiratory Syncytial Virus - Recombinant respiratory syncytial viruses characterized
Respiratory Syncytial Virus - V beta 14+ T cells mediate disease induced by RSV G glycoprotein
Retinal Regeneration - First derivation of retinal cells from embryonic stem cells; may treat blindness
Retrovirus - NC structural interactions with other Gag domains necessary for Psi RNA binding
Rheumatology - Cyclooxygenase inhibitors block enzymes that promote rheumatoid arthritis
SARS Coronavirus - Pivotal role of SARS coronavirus E protein in viral budding elucidated
Spinal Cord Injury - Protective effects of anti-CD11d antibody clarified
Spinal Cord Injury - Structure of Nogo-A protein characterized
Stem Cell Research - Nestin expression lost in neural stem cells through proteasome/Notch signaling
Stem Cell Research - PGE2 produced by COX-2 increases BMP-2 expression via binding the EP4 receptor
Streptococcus Vaccine - Group A Streptococcus strains causing epidemics analyzed
Systemic Lupus Erythematosus - Detoxification deficiency linked to increased oxidative stress in SLE etiology
Timothy Syndrome - Researchers determine genetic cause of cardiac disorder
Tissue Engineering - U.S. Army evaluating recombinant human fibrinogen product
Tobacco Use - Nicotine metabolism characterized in subjects with CYP2A6 deletion
Transplant Medicine - Genetic signatures profile kidney transplant rejection status
Tuberculosis Diagnosis - ESAT-6 and CFP-10 protein peptides used to detect M. tuberculosis
Vasoconstriction - Findings should lead to the design of new, potent, and selective analogues
Viral Proteomics - Hepatitis C virus F protein and core protein are dissimilar
Virology - Coliphage PR772 evaluated for use in virus filter performance testing
Virology - Genetically modified adenoviruses show promise for treating gliomas
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