Drug Development
Flavin-dependent thymidylate synthase activity characterized
Published in Proteomics Weekly, October 18th, 2004
"The ThyA gene that encodes for thymidylate synthase (TS) is absent in the genomes of a large number of bacteria, including several human pathogens," scientists in the United States explained. "Many of these bacteria also lack the genes for dihydrofolate reductase (DHFR) and thymidine kinase and are totally dependent on an alternative enzyme for thymidylate synthesis."
"Thy1 encodes flavin-dependent TS (FDTS, previously denoted as TSCP) and shares no sequence homology with classical TS genes," noted N. Agrawal and colleagues at the University of Iowa, who...
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Source: Proteomics Weekly (2004-10-18)
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