Arthritis

TNF inhibitor therapy may increase risk of serious postoperative infection

Published in Proteomics Weekly, November 15th, 2004

TNF inhibitor therapy, which has proved successful in reducing inflammation in patients with rheumatoid arthritis, may increase the risk of serious postoperative infections when taken prior to orthopedic surgery, according to research presented at the American College of Rheumatology Annual Scientific Meeting in San Antonio, Texas.

Genetically engineered, or biologic, tumor necrosis factor (TNF) inhibitors suppress the TNF proteins that cause joint inflammation, a beneficial therapy in the day-to-day lives of many arthritis patients. However, because the same TNF protein also plays a key role in suppressing infections with certain bacteria in the body, continued use of...

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Source: Proteomics Weekly (2004-11-15)

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