Rheumatology

Interleukin-18 overexpression drives interleukin-1-related cartilage damage

Published in Proteomics Weekly, November 15th, 2004

Interleukin-18 overexpression drives interleukin-1-related cartilage damage.

According to a study from the Netherlands, "interleukin (IL)-18 is a member of the IL-1 family of proteins that exerts proinflammatory effects and is a pivotal cytokine for the development of Th1 responses. The goal of the present study was to investigate whether IL-18 induces joint inflammation and joint destruction directly or via induction of other cytokines such as IL-1 and tumor necrosis factor (TNF). To this end we performed both in vitro and in vivo kinetic studies."

"For in vivo IL-18 exposure studies C57BL/6, TNF-deficient, and IL-1-deficient mice were injected...

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Source: Proteomics Weekly (2004-11-15)

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