Hypertrophy
Chronic activation of Cdk9 causes defective mitochondrial function
Published in Proteomics Weekly, November 15th, 2004
Scientists writing in the EMBO Journal report, "Hypertrophy allows the heart to adapt to workload but culminates in later pump failure; how it is achieved remains uncertain. Previously, we showed that hypertrophy is accompanied by activation of cyclin T/Cdk9, which phosphorylates the C-terminal domain of the large subunit of RNA polymerase II, stimulating transcription elongation and pre-mRNA processing; Cdk9 activity was required for hypertrophy in culture, whereas heart-specific activation of Cdk9 by cyclin T1 provoked hypertrophy in mice."
M. Sano and...
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Source: Proteomics Weekly (2004-11-15)
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