Proteomics Weekly

Glycemic Control - Short-term chemical ablation of GIP receptor causes glucose intolerance

HIV/AIDS Research - Conserved carboxy terminus of HIV-1 Gag important for virion assembly/release

HIV/AIDS Research - Hsp70 protects cells from cell cycle arrest and apoptosis induced by HIV-1 Vpr

HIV/AIDS Research - IgMs selectively cleave HIV gp120 by a nucleophilic mechanism

HIV/AIDS-Related Wasting Syndrome - Hyperphagia contributes to normal body composition in asymptomatic HIV infection

Haemophilus Vaccine - Intranasal vaccine reduces colonization of Haemophilus influenzae

Heart Failure - Corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium

Herpesvirus - E2F1/CDK2 promoter activation requires N- and C-terminal regions of KSHV LANA

Herpesvirus - Kaposi sarcoma-associated herpesvirus immediate early gene activity explored

Heymann Nephritis - Chemically modified renal antigen produces Heymann nephritis

Human Papillomavirus Vaccine - ISCOMATRIX adjuvant is suitable for use in anticancer vaccines

Huntington Disease - Role of adenosine in neurodegeneration elucidated

Hypertension - ROS-induced Ca²⁺ sensitization is through activation of Rho

Hypertension Risk Factor - Renin-angiotensin system activated in rats with obesity and hypertension

Immune Respose - Cell surface MHC class II expression inhibited by Salmonella

Immunology - Fas ligand overexpression spawns inflammation in the central nervous system

Immunology - Immunoassay for gp130 binding to IL-6/lL-6R complex devised

Immunology - Nitric oxide regulates PMN-brain microvessel endothelial cell interactions

Immunology - Novel assay provides simultaneous measure of serum and PBMC cytokines

Influenza Vaccine - Stability of influenza hemagglutinin in vaccine bulk material studied

Information Technology - Software for life sciences study and research launched

Insulin Resistance - Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats

JC Virus - PMA and IL-1beta dramatically increase JC virus transcription in glial cells

Kaposi Sarcoma Herpesvirus - KSHV ORF36 protein kinase activates c-Jun N-terminal kinase signaling pathway

Leptin Studies - Leptin and insulin downregulate angiopoietin-like protein 3

Leukemia - Orphan drug designation granted for the treatment of leukemia

Leukemia - Signaling mechanisms underlie human leukemia cell life/death switching

Lipid Metabolism - Use of SNPs doubles estimates of genetic variance of HDL and APOE AI in women

Liver Transplantation - Hepatic Na⁺, K⁺-ATPase reduced after ischemia-reperfusion

Malaria - Malaria protein that binds to placental cells may serve as vaccine target

Malaria Genomics and Genetics - Genetic diversity of malaria merozoite protein gene determined

Malaria Vaccine - Malaria vaccine based on Plasmodium Duffy binding protein evaluated

Meningococcal Vaccine - Putative vaccine antigens from Neisseria meningitidis identified

Mental Health - X-box binding protein 1 C--116G polymorphism is not linked to bipolar disorder

Mergers & Acquisitions - Biopharmaceutical company acquires minority interest in TKT Europe-5S AB

Molecular Biology - HNA gapmer oligonucleotides supply potent antisense activity

Motor Neurons - Embryonic SC-derived motoneurons develop appropriate transmitter receptors

Murine Leukemia Virus - Real-time PCR evaluates X-MuLV removal during protein purification

Muscular Dystrophy - Calsequestrin expression reduced in dystrophic murine skeletal muscle

Myocardial Infarction - Interruption of the Fas/Fas ligand system may treat heart failure

Myocardial Infarction - Positive results from clinical trial of arterial inflammation drug

Neuroblastoma Therapy - Microtubule alterations identified in drug-resistant tumor cells

Neuroscience - Antiangiogenic protein fragments harbor amyloid characteristics

Neurotransmission - Dopamine blocks the effects of vascular growth factors on endothelial cells

Nicotine Addiction - Receptor subunit could be prime culprit for addiction response to nicotine

Obesity Pathogenesis - Ghrelin and Agouti-related protein increases food intake

Obesity Pathogenesis - Resistance to obesity in A/J mice not linked to hypothalamic neuropeptides

Obesity Therapy - Lysophosphatidic acid is bioactive phospholipid

Oncogenesis - Adenoma to carcinoma hTR expression not linked to promoter methylation

Oncogenesis - Hepatitis B X protein blocks transcription-coupled nucleotide excision repair

Oncogenesis - Members of the RB/E2F family of proteins cause aberrant survivin expression

Oncology - KL-6 is a serological marker for liver cancer in patients with hepatitis C

Ophthalmology - Smad7 gene transfer retains epithelial integrity in injured murine eyes

Osteoblasts - Extracellular mineral surfaces play role in gene expression regulation

Ovarian Cancer - Inhibitory protein involved in cancer cell apoptosis and cisplatin sensitivity

Pain Management - Biopharmaceutical company presents information on chronic opiod use

Pain Medicine - NMDA receptors in anterior cingulate cortex mediate pain-induced aversion

Pain Medicine - Spinal PAR stimulation induces thermal hyperalgesia

Parkinson Disease - ACE inhibitor perindopril protects against MPTP-induced neurodegeneration

Percutaneous Coronary Intervention - Integrin beta3 regions that control binding of murine mAb 7E3 identified

Personnel - BioSciences company adds to scientific advisory board

Personnel - Drug development company board elects Hans C. Noetzli as new director

Prostate Cancer - Luteinizing-hormone-releasing-hormone causes prostatic atrophy

Prostate Cancer - Vitamin D₃ -modulated genes identified in prostate tumor cells

Protein Signaling - Notch4 requires ankyrin repeats to staunch endothelial sprouting

Proteomics - Database of therapeutically relevant multiple pathways developed

Proteomics - Expression, function of drug transport proteins studied in rat liver model

Proteomics - Rad9 acts as a transcriptional activator of gene expression

Pulmonary Hypertension - Serotonin causes nuclear translocation of ERK1/ERK2 in cell mitogenesis

Pythiosis Therapy -  Pythium insidiosum antigens effective against vascular pythiosis

Reproductive Biology - Iron transport protein activity increases in normal third trimester placenta

Reproductive Endocrinology - Oxidized LDL modulation of human trophoblast invasion studied

Rotavirus - Rotavirus serotype G9P[8] responsible for outbreak in Northern Australia

Salmonella Vaccine -  Salmonella flagellin induces systemic and mucosal immune responses

Schizophrenia - New data show metabolic and protein processing deficits may cause schizophrenia

Serotonin - Pharmacology of serotonin reviewed

Skeletal Myoblast Transplantation - Skeletal myoblast grafts generated heterogeneity of Ca²⁺_i ) signaling

Skin Cancer - Researchers discover potential skin cancer prevention target

Stem Cell Research - Hypoxia triggers stem cell proliferation followed by neuronal SC differentiation

Stem Cell Research - Molecular phenotype of renal progenitor cells identified

Stroke - Endogenous FGF-2 ameliorates ischemic brain damage in rats

Systemic Lupus Erythematosus - Biomarkers could lead to quicker and better diagnosis

Systemic Lupus Erythematosus - Newly identified biomarkers could lead to quicker, better diagnosis of lupus

Tuberculosis Vaccine - CD27-negative CD4 T cells produce IFN-gamma upon mycobacteria challenge

Tuberculosis Vaccine - Chronic pneumonia occurs despite immune response to BCG

Tuberculosis Vaccine - New M. tuberculosis antigens are promising vaccine candidates

Tumor Suppression - Mutant p53 influences hypoxia-induced gene expression in tumor cells

Type 2 Diabetes - Data demonstrate the potential of arimoclomol for the treatment of diabetes

Urology - Vascular endothelial growth factor shares in prostate blood flow regulation

Uterine Leiomyomas - Protein's potential anti-apoptotic function may play role in fibroid growth

Vaccine Adjuvant - Artificial peptide induces Th2 immune response to antigens

Vaccine Adjuvant - CD40 antibody as adjuvant induces enhanced T cell responses

Vaccine Adjuvant - Non-toxic Stx derivatives from E. coli possess adjuvant activity

Vaccine Adjuvant - Protollin is novel adjuvant for intranasal vaccines

Vaccine Development - License agreement reached for MedPulser DNA Delivery System in two applications

Ventricular Arrhythmias - Study examines molecular mechanisms that predispose hearts to arrhythmias

Virology - CMV UL76 encodes novel virion-associated protein that inhibits viral replication

Virology - Polyplexes containing chitosan oligomers improve non-viral gene delivery

Weight Gain - Receptor polymorphisms associated with midlife weight gain

Wound Healing - Novel AP-1 target genes identified in cutaneous-repair fibroblasts