Proteomics Weekly

Cancer Therapy - G-quartet oligonucleotides targeting Stat3 protein fight cancer growth

Development - p38 pathway regulates transcription, translation of Akt during myogenesis

Drug Development - Scaffold-stabilized peptides foster the identification of new drug targets

Hormones - Estrogen controls branched-chain amino acid catabolism in female rats

Phosphorylation - Norepinephrine regulation and diurnal rhythm of protein kinase phosphorylation

Renal Disease - Fatty acid-binding protein in urine denotes proximal tubule stress overload

AIDS/HIV Vaccine - Recall antigen activation induces prompt release of CCR5 ligands from PBMC

AIDS/HIV Vaccine - Seventeen SIV-derived CD8+ T cell Mamu-A*02-restricted epitopes identified

AIDS/HIV Vaccine - Tat protein elicits production of neutralizing antibodies

Adrenergic Receptors - Beta₁ -AR can undergo PKA-dependent "G_s /G_i switching"

Adrenergic Receptors - Beta₁ AR stimulation activates dual signaling pathways

Allergy Medicine - Fluticasone-mediated airway inflammatory response to organic dust determed

Allergy Medicine - New peanut immunotherapy inhibits allergic response in preclinical studies

Allergy Vaccine - Epitope modulation of Bet v 1 reduces IgE binding but retains protein folding

Alzheimer Disease - A novel presenilin 1 mutation (Y154N) discovered in early onset AD

Alzheimer Disease - Apo and inhibitor complex structures of beta-secretase determined

Alzheimer Disease - Choline acetyltransferase supplementation may slow Alzheimer disease

Alzheimer Disease - Memantine improves spatial learning in an Alzheimer mouse model

Alzheimer Disease - Molecular modeling of the core of beta amyloid fibrils reported

Alzheimer Disease - Semaphorin 3A activity may contribute to hippocampal degeneration

Analgesia - Ketamine potentiates the effect of electroacupuncture on mechanical allodynia

Antibiotics - Scorpion-derived antimicrobial peptide IsCT and its analogs analyzed

Antimicrobials - Antibacterial principle of Caesalpina sappan revealed

Apoptosis - CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes

Apoptosis - H2AX phosphorylation at short telomeres in T cells and fibroblasts demonstrated

Apoptosis - Mitochondrial network blocks intraorganellar Ca²⁺ waves

Arthritis - Gelatinases and septic arthritis of native and replaced knees

Asthma - Abnormal alveolar attachments with decreased elastic fiber seen in fatal asthma

Asthma - Adenosine linked to mucin over-expression in asthma

Asthma - Extracellular matrix regulates human airway smooth muscle cell migration

Atherosclerosis - PLTP deficiency decreases atherosclerosis in mouse models

Atherosclerosis - Role of antibodies to oxidized LDL in atherosclerosis development reviewed

Atherosclerosis - Thiazolidinediones reduce expression of RAGE

Autism - Oxidative stress reported increased in autism

Autoimmune Disease - New protein structure may aid in design of therapeutics

Autoimmune Disease - Therapeutic vaccines in autoimmunity reviewed

Bacteriology -  E. coli genomic cold shock response characterized

Bacteriology - Transcriptional activity of E. coli MelR protein characterized

Bioinformatics - Novel methods map RNA secondary structures in hepatitis C virus genome regions

Biomarkers - The ratio of VEGF-A to its soluble receptor changes in breast cancer patients

Biotechnology - Marine bacteria screened for alpha linolenic acid

Brain Injury - Myoinositol detection studied in children with traumatic brain injury

Breast Cancer - Black tea polyphenols may inhibit hormone-dependent breast tumors

Breast Cancer - Breast tumor expression of EGFR family proteins has prognostic value

Breast Cancer - CTCF not target of 16q22.1 loss in breast carcinoma

Breast Cancer - High geminin expression predicts adverse outcome in breast cancer patients

Breast Cancer - Study finds chemical attraction makes HER2-positive breast cancer invade organs

Business & Finance - DNA-focused pharmaceutical reports on "challenging" quarter

Business Update - EMD Biosciences enters into a cooperative agreement for antibody products

COX-2 Inhibitor - RNA-binding protein CUGBP2/COX-2-mediated PGE2 antagonistic in radiation damage

Calcium Channel - Splice variation furnish reference library for studying Ca_V 1.2 splice exons

Cancer Research - 'Handcuffing' and unpairing controls of P1 plasmid replication

Cancer Therapy - Down syndrome protein reduces tumor growth

Cancer Therapy - Study may lead to new means of improving existing cancer treatments

Cancer Vaccine - Antibody response improved after antigen-pulsed dendritic cell vaccine

Cancer Vaccine - Unique antigens for therapeutic cancer vaccines reviewed

Cardiac Myofibroblasts - Sp1 may interact with with PKCdelta and MAPK in type I collagen expression

Cardiology - Myosin-binding protein C stabilizes the structure of the thick filament

Cell Biology - A molecular light switch silences neurons

Cell Biology - BAP31 linked to intracellular trafficking of CD11b/CD18 in neutrophils

Cell Biology - Fluorescence reveals ubiquitination dynamics

Cell Biology - Glycocalyx modulates shear-dependent albumin uptake in endothelial cells

Cell Biology - Novel genetic screen used to identify Drosophila S-phase entry regulators

Cell Biology - Stem cells' repair skills might be linked to cancer

Cell Membranes - Report describes the structure of cell membranes

Cellular Signaling - Tissue distribution, calmodulin expression regulation studied in goldfish

Chlamydia - Chlamydia inhibit host-cell apoptosis by degrading proapoptotic proteins

Chronic Obstructive Pulmonary Disease - Chemokines in bronchiolar epithelium play key role in COPD pathogenesis

Cirrhosis - Dietary nucleotides reduce liver damage in cirrhotic rats

Collaborations - Genentech inks agreement for anti-NGF antibody for acute and chronic pain

Colorectal Cancer - Proteomic assay used to determine P450 profile in colorectal tumor metastases

Contraceptive Vaccine - Fusing molecular adjuvant to hCG protein antigen enhances humoral immunity

Creutzfeldt-Jakob Disease - Survival predicted by correlates in sporadic Creutzfeldt-Jakob disease

Critical Care Medicine - Tissue protection from delay phenomenon mediated by heme oxygenase-1

Cystic Fibrosis - Neutrophil peroxidase activity and pulmonary phenotype in cystic fibrosis

Cystic Fibrosis - Transcriptional regulator AlgR controls P. aeruginosa cyanide production

Cytoprotection - Role of glutathione in the adaptive tolerance to hydrogen peroxide

DNA Research - A three step process delineates the handoff of UvrA to UvrB during DNA repair

DNA Research - H-1 paramagnetic relaxation enhancement characterizes protein-DNA interactions

DNA Research - Protein interactions facilitate repair following oxidative DNA damage

Dermatology - The hairless protein regulates epithelial cell differentiation in the skin

Development - Molecular analysis of laminin N-terminal domains mediating self-interactions

Development - Multiple pools of phosphatidylinositol 4-phosphate detected

Development - Synaptic Ras-GTP-ase activating protein regulates spine formation

Diabetes Complications - F₂ isoprostane already increased at onset of type 1 diabetes

Diabetes Complications - Inactivation of complement protein involved in diabetes complications

Diabetes Genomics and Genetics - Gene encoding WNT5B linked to type 2 diabetes

Diabetes Genomics and Genetics - Genes protective against type 1 diabetes found on rat chromosome 6q32

Diabetes Genomics and Genetics - Region conserved with diabetes loci identified in human chromosome 1q

Diabetes Pathogenesis - Free insulin-like growth factors reviewed

Diabetes Pathogenesis - Neuronal gluco-sensing in diabetes reviewed

Diabetes Pathogenesis - Vitamin D receptor gene sequence variants in type 1 diabetes analyzed

Diabetes Therapy - INGAP peptide improves nerve function and regeneration in diabetes

Diabetic Neuropathy - PKC-alpha mediates indoleamine content changes in diabetic rat brain

Diagnostics - Use of biomarkers to detect cervical dysplasia, cancer a 'success'

Diet & Nutrition - Gastric ghrelin inhibition by food intake dependent on macronutrients

Disease Associations - Tetraspanin crucial for basement membrane assembly in kidney and skin

Drug Delivery - Biodegradable composite microspheres show promise for protein delivery

Drug Delivery - Protein particle size significantly affects microsphere release rate

Drug Development - Absorptive and secretory quotient values for Pgp substrates determined

Drug Development - Anti-Nogo66 receptor antibody may promote CNS repair

Drug Development - Drug discovery and screening companies announce new collaboration

Drug Development - Novel assay screens anti-SARS drugs

Drug Development - Pharmaceutical company announces new research collaboration

Drug Development - Researchers use crystals to help battle deadly diseases

Drug Discovery - Biotechnology company expands PharmaCarta collaboration with Serono

Drug Metabolism - Cytochrome P450 isoforms involved in ethinylestradiol metabolism identified

Drug Metabolism - Effects of uremic toxins on hepatic processing of erythromycin determined

Drug Metabolism - MDMA is a potent mechanism-based CYP2D6 inhibitor

Endocrinology - Growth hormone treatment raises serum COMP levels in prepubertal children

Endocrinology - Peroxisome proliferator exposure may alter retinoic acid metabolism

Environmental Health - Effects of amitraz on P450 and estrogen activity determined

Environmental Health - Effects of cadmium exposure on male sex hormones characterized

Enzymology - Amphilic interface between enzymes reported

Enzymology - Metalloprotease-2 is involved in human brain neovascularization

Enzymology - Polymorphism in a key folate enzyme influences DNA methylation in young women

Enzymology - Telomerase-transduced cells may treat human diseases

Epilepsy - Electrophysiology of mouse gamma-aminobutryic acid receptors

Epilepsy Therapy - Clobazam metabolism by cytochrome P450 enzymes characterized

Erythropoiesis - Human heme exporter that is essential for erythropoiesis identified

Fibrinogen - Alpha_M I-domain and has the potential to recognize numerous sequences

Finance - Cancer/inflammation-focused company reports smaller loss in Q3