Published in Proteomics Weekly, December 13th, 2004
C.L. Chik and colleagues of the University Alberta demonstrated that NE increased the levels of phosphorylated MAPK kinase 3/6 (MKK3/6) and p38MAPK in rat pinealocytes in a dose-dependent fashion.
Time-course studies showed a gradual increase in MKK3/6 and p38MAPK phosphorylation that peaked between 1 and 2 h following NE stimulation and persisted for 4 h.
The inclusion of prazosin or propranolol with cells treated with NE for 2...
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