Phosphorylation

Norepinephrine regulation and diurnal rhythm of protein kinase phosphorylation

Published in Proteomics Weekly, December 13th, 2004

The effects of the endogenous neurotransmitter norepinephrine (NE) on the regulation and diurnal rhythm of the p38 mitogen-activate protein kinase (p38MAPK) from the rat pineal gland have been clarified.

C.L. Chik and colleagues of the University Alberta demonstrated that NE increased the levels of phosphorylated MAPK kinase 3/6 (MKK3/6) and p38MAPK in rat pinealocytes in a dose-dependent fashion.

Time-course studies showed a gradual increase in MKK3/6 and p38MAPK phosphorylation that peaked between 1 and 2 h following NE stimulation and persisted for 4 h.

The inclusion of prazosin or propranolol with cells treated with NE for 2...

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Source: Proteomics Weekly (2004-12-13)

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