Proteomics Weekly

Atherosclerosis - Lipoprotein induction of chemotactic protein-3 in atherosclerosis

Epilepsy - Overexpressed neuropeptide Y may protect against hyperexcitability

Infection - HCMV induces rapamycin-insensitive phosphorylation of mTOR kinase effectors

Osteoarthritis - Collagen synthesis, regulatory molecule expression studied in osteoarthritis

Pediatrics - A protein in breast milk helps prevent and treat deadly neonatal enterocolitis

Physiology - Integrin-mediated cellular functions selectively inactivated

AIDS/HIV Pathogenesis - DC-SIGN interference inhibits HIV transmission from dendritic to T cells

Alcohol Abuse - Ferulic acid influences prooxidant antioxidant status

Allergy Medicine -  Stellaria dichotoma beta-carboline-type alkaloids are antiallergic

Allergy Medicine - Chimeric protein microarray useful for structural epitope screening

Alzheimer Disease - Beta-amyloid (1-42)-induced learning and memory deficits in mice

Alzheimer Disease - Findings show how toxic proteins rob AD patients of memory

Alzheimer Disease - Increased endocytotic pathway-mediated A beta 42 secretion in apoptosis

Amyotrophic Lateral Sclerosis - ALS2CL binds to Rab5 and modulates endosome dynamics

Amyotrophic Lateral Sclerosis - Effect of p75 neurotrophin receptor antagonist on ALS reported in murine model

Amyotrophic Lateral Sclerosis - Promising results seen in the battle against incurable muscle disease

Anti-Infectives - Yeast killer toxin-like antibodies possess therapeutic potential

Antipsychotic Treatment - Clozapine enhances chronic PCP-induced regulation of prefrontal cortex receptors

Apoptosis - Activated NK/CD8+ cells express TRAIL and TRAIL receptors

Apoptosis - Apoptosis-inducing factor orthologue regulates apoptosis in yeast

Apoptosis - DNA-dependent protein kinase can phosphorylate Ser⁴⁶ of human p53

Apoptosis - Infrared radiation affects apoptosis mitochondrial pathway in human fibroblasts

Apoptosis - Raf/MEK/ERK pathway block sensitizes AML cells to lovastatin-induced apoptosis

Atherosclerosis - Endothelial phenotype of susceptible and resistant vasculature characterized

Atherosclerosis - Lercanidipine may inhibit macrophage functions involved in plaque stability

Biotechnology - Aspartic to serine proteinase redesigned in catalytic center of porcine pepsin

Breast Cancer - Autocrine Epo signaling inhibits hypoxia-induced apoptosis in cancer cells

Breast Cancer - Novel protein pathway linked to aggressive progression of breast cancer

Business & Finance - DNA identity services provider affirms quality assurance procedures

Business Update - Biosample-management company announces global expansion

Business Update - Partnership to combine information technology with biotech research formed

CNS Synapses - Lasp-1 is a component of synapses and dendritic spines

Caenorhabditis Elegans - TetraThymosin beta and actin dynamics in C. elegans studied

Cancer Therapy - Coramsine proven effective in treating mesothelioma in a mouse model

Cancer Vaccine - Novel pro-apoptotic peptide impairs phosphorylation by protein kinase 2

Carcinogenesis - Innovative technology leads to new insights on carcinogenesis

Cardiology - MaxiK channel beta 1 subunit decreases with coronary artery ageing

Cardiology - Prazosin requires endothelial NOS to generate skeletal muscle angiogenesis

Cardiology - The antifibrosis peptide Ac-SDKP may prevent and treat cardiac disorders

Cardioprotection - A PKC-tyrosine kinase module may be involved in pharmacological cardioprotection

Cardiovascular Disease - Urokinase product ThromboClear entering manufacturing stage

Cardiovascular Research - Approach provides new venues for inquiry into ANG II-mediated cardiac function

Cardiovascular Research - Study sought to identify ERRalpha-regulated pathways in heart tissues

Cell Biology - Dynein/dynactin complex regulates mitochondrial morphology

Cell Biology - Kinectin function elucidated

Cell Biology - Lis-1 needed for dynein-dependent cell division in C. elegans embryos

Cell Biology - Novel centrosomal proteins identified

Cell Biology - Organized, intranuclear filament network in living mammalian cells visualized

Cell Signaling - Researchers honored for work on signal transduction in cells

Cell-Cycle Analysis - Company launches Cell Cycle assay

Channel Opening - Cation channels opened by muscarinic stimulation with carbachol

Cholera - Association of cytoskeleton with cholera toxin-ganglioside complex

Chronic Obstructive Pulmonary Disease - Genes linked to COPD pathogenesis identified

Collaborations - Companies to offer pharmacogenomic technologies for oncology drug development

Collaborations - Genes-to-leads drug discovery deal signed

Colon Cancer - Antibody developed that penetrates mutant p53 colon cancer cells and binds p53

Colorectal Cancer - CDX2 useful as marker for colorectal adenocarcinoma

Congestive Heart Failure - Scientists use gene therapy to rescue failing hearts in animals

Cystic Fibrosis - Genomic effects of Pseudomonas on CF cells determined

Cytomegalovirus - Inhibition of human cytomegalovirus replication involves three mechanisms

DNA Research - DNA identity labs awarded $1.9 million for National Missing Persons Initiatives

DNA Research - Novel DNA hybridization assays using temperature gradient focusing developed

Depression - Differential effects of agomelatine versus fluoxetine in the rat brain

Diabetes Complications - Hypoglycemic effects of bioflavonoids mediated by hepatic enzymes

Diabetes Complications - Thyroiditis in diabetic mice lacking IFN regulatory factor examined

Diabetes Genomics and Genetics - Missense mutations in glucagon-like peptide 1 receptor gene found

Diabetes Pathogenesis - Calcitonin gene-related sensory neurons lost in early diabetes

Diabetes Pathogenesis - Dendritic cells lead to type 1 diabetes in CD154-expressing mice

Diabetes Pathogenesis - Expression profiling of insulin action in human myotubes reviewed

Diabetes Pathogenesis - Fatty acids and cytokines kill beta-cells by different mechanisms

Diabetes Pathogenesis - Glucose intolerance develops in mice overexpressing glycogen kinase

Diabetes Pathogenesis - IGF-I decline in induction of atrogin-1/MAFbx in diabetes studied

Diabetes Pathogenesis - Microarray analysis of IgG autoantibodies predicts diabetes in mice

Diabetic Endocardiopathy - Cardiac mitochondrial damage and biogenesis in type 1 diabetes studied

Diabetic Nephropathy - Advanced glycation end-products involved in organic cation transport

Diagnostics - Patent issued for optical waveguides and molecular diagnostics device

Disease Associations - Pulmonary EC-SOD is redistributed after asbestos exposure

Drug Delivery - Peripheral tissues express transgenes after oral polyplex-based DNA vaccination

Drug Development - In silico tool predicts cytochrome P450 2D6 inhibition

Drug Development - Novel stilbenoid has potent anti-tumor activity

Drug Metabolism - Cytochrome P450 3A4 plays leading role in aprepitant metabolism

Drug Metabolism - Metabolism of cyclosporine A by kidney CYP3A5 characterized

Drug Metabolism - Miniature on-line screening system for UGT inhibitors developed

Duchenne Muscular Dystrophy - Progression of kyphosis in a mouse model of muscular dystrophy documented

E. coli - Protein keeps pathogenic bug from infecting skin

Electrophoresis - Novel microchip system facilitates quantitative protein analysis

Endocrinology - Frog metamorphosis characterizes the molecular dynamics of thyroid hormone

Endocrinology - Luteinizing hormone receptor in Leydig cell hypoplasia

Endocrinology - Transcriptional response to CRF characterized in mouse pituitary cells

Endocriology - Parathyroid hormone gene variants do not spawn idiopathic hypoparathyroidism

Endometriosis - Dysregulation of IL-1/IL-1-R system may relate to immunologic dysfunction

Enzymology - Binding of theophylline and adenosine deaminase characterized

Enzymology - Losses of enzymatic activities in rat brain and liver mitochondria

Enzymology - NADPH oxidase could be targeted for the treatment of cancer or heart disease

Enzymology - Peptidoglycan amidase MepA is a LAS metallopeptidase

Enzymology - Researchers propose series of reactions involved in conversion of DNA to CO-DNA

Enzymology - Sleeping Beauty transposase can be altered to improve genetic research

Female Diabetes - PPAR-gamma activation affects nitric oxide production in placenta

Foamy Virus - Feline foamy virus Tas protein is a DNA-binding transactivator

Gastroenterology - Protein kinase B/Akt isoforms affect epithelial cell survival and anoikis

Gastroenterology - Sildenafil influences gastric sensorimotor function in humans

Gastrointestinal Research - Signaling studied in smooth muscle mediated by ETA and ETB

Gene Analysis - Targeted DNA photocleavage detects single-nucleotide polymorphisms

Gene Expression - GenUs BioSystems to provide outsourced gene-expression profiling services

Gene Promoters - G-quadruplex ligands may stop c-myc activity in tumor cells

Gene Transfer - Central leptin gene therapy shows promise for diminishing obesity

Gene Transfer - Copper/zinc superoxide dismutase enhances VEGF synthesis

Genetic Disorders - A novel RAB7 mutation associated with ulcero-mutilating neuropathy

Genetic Mutations - Cytochrome c oxidase biogenesis in a patient with a COX10 mutation

Genomics - CLBP and cardiotoxin genes diverged before appearance of numerous cardiotoxins

Genomics and Genetics - Calcium-mediated response to alkaline stress characterized in S. cerevisiae

Glaucoma - Age-related changes seen in trabecular meshwork cells

Growth & Differentiation - Osteoblast stage determines stretch-induced phosphorylation of ERK1/2

Growth Hormones - Continued growth hormone treatment after final height needed

Gynecology - Ether a go-go is a biomarker for human cervical cancer

HIV/AIDS - Proof-of-principle results for HIV drug candidate released

HIV/AIDS Research - HIV-1 virus-like particles lacking nucleocapsid domain fail to package APOBEC3G

HIV/AIDS Research - Selected AA substitutions in C-terminal region of HIV-1 CA affect virus assembly

Heart Failure - Data may explain salutary effect of adenylyl cyclase type VI in failing hearts

Helicobacter Vaccine - Glycoconjugates with NeuAc-NeuAc-GaL-Glc prevent H. pylori adhesion

Hematology - Imaging details, pathological differences of red blood cells seen in lupus

Hematology - Structure of erythrocyte NADH-cytochrome b₅ reductase determined

Hepatic Innervation - Scientist investigate the role of innervation in sinusoidal diameter regulation

Herpetic Stromal Keratitis - Interleukin-1 receptor antagonist counteracts HSV-related corneal inflammation

Hormone Deficiency - Adults with PROP-1 gene mutations grow upon receiving hormone therapy

Hormones - Estrogen accelerates occludin modulation at tight junctions

Hormones - Thyroid hormones regulate DNA-synthesis and cell-cycle proteins

Human Papillomavirus Vaccine - Papillomavirus-like particles stimulate dendritic cells to produce IFN-alpha

Huntington Disease - Fine retina structure and connexin expression in Huntington disease detailed

Huntington Disease - Group blocks formation of toxic protein clumps seen in HD

Hypercalciuria - Monocyte vitamin D receptors elevated in idiopathic hypercalciuria

Hypertension - Lentiviral vectors bear clones that offer long-term ACE2 secretion

Imaging - 3-D imaging of Toxoplasma gondii, host-cell interactions reported

Immunology - Enhanced expression of cell cycle regulatory genes found in CD8+ T cells

Immunology - Functional properties of CD27⁺ memory T cells determined

Immunology - Gene expression of IL-10-induced myeloid DC characterized

Immunology - Novel CS1 splice variant identified in natural killer cells

Immunology - Regulated production of chemokine CCL28 in colon epithelium described

Immunology - Roles of prostaglandin receptors are determined by multiple factors

Immunology - TLR-induced macrophage transcriptional activation characterized

Infection -  Plasmodium falciparum-infected erythrocytes bind to fibronectin