Epilepsy
Overexpressed neuropeptide Y may protect against hyperexcitability
Published in Proteomics Weekly, December 20th, 2004
According to published research from Italy, "recurrent epileptic seizures in the rat enhance the expression of neuropeptide Y (NPY) and its mRNA in various brain areas including the hippocampus, cerebral cortex and the amygdala. In the hippocampus, the most prominent expression of NPY is observed in mossy fibers and in GABAergic interneurons. At the same time, expression of Y2 receptors is also increased whereas Y1 receptors are reduced."
"Similar changes in Y1 and Y2 receptors were observed in the hippocampus of patients with temporal lobe epilepsy (TLE). In contrast to the rat, NPY...
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Source: Proteomics Weekly (2004-12-20)
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