Infection

HCMV induces rapamycin-insensitive phosphorylation of mTOR kinase effectors

Published in Proteomics Weekly, December 20th, 2004

According to researchers from the United States, an infection with human cytomegalovirus (HCMV) induces rapamycin-insensitive phosphorylation of downstream effectors of mammalian target of rapamycin (mTOR) kinase.

"Signaling mediated by the cellular kinase mammalian target of rapamycin (mTOR) activates cap-dependent translation under normal (nonstressed) conditions," wrote S.B. Kudchodkar and colleagues, University of Pennsylvania.

"However," the authors explained, "translation is inhibited by cellular stress responses or rapamycin treatment, which inhibit mTOR kinase activity."

"We show that during human cytomegalovirus (HCMV)...

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Source: Proteomics Weekly (2004-12-20)

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