Disease Associations
Pulmonary EC-SOD is redistributed after asbestos exposure
Published in Proteomics Weekly, December 20th, 2004
"Inhalation of asbestos fibers leads to interstitial lung disease (asbestosis) characterized by inflammation and fibrosis. The pathogenesis of asbestosis is not fully understood, but reactive oxygen species are thought to play a central role," wrote R.J. Tan and colleagues, University of Pittsburgh.
"Extracellular superoxide dismutase (EC-SOD) is an antioxidant enzyme that protects the lung in a bleomycin-induced pulmonary fibrosis model, but its role has not been studied in asbestos-mediated disease.
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Source: Proteomics Weekly (2004-12-20)
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