Hormones

Overexpression of serotonin(1A) receptors linked to reduced anxiety

Published in Proteomics Weekly, January 3rd, 2005

Researchers from the Netherlands have reported on the reduced anxiety-related behaviour in transgenic mice overexpressing serotonin(1A) receptors."Serotonergic neurons play a major role in the modulation of emotion and behavior," scientists writing in the journal Molecular Brain Research report.

"Especially knockout studies have revealed a role for the serotonin(1A) (5-HT1A) receptor in anxiety related behaviour. Mutant animals exhibit enhanced anxiety-like responses, possibly resulting from impaired autoinhibitory control of midbrain serotonergic neurons.

"To further elucidate the role of the 5-HT1A receptors in affective behaviour, a...

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Source: Proteomics Weekly (2005-01-03)

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