Metaplasia

Metaplasia and gene induction analyzed, Notch modulation revealed

Published in Proteomics Weekly, January 3rd, 2005

Researchers from the United States have reported that the modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

"It is anticipated that gamma-secretase inhibitors (gamma-Sec-I) that modulate Notch processing will alter differentiation in tissues whose architecture is governed by Notch signaling," wrote J. Milano and colleagues, AstraZeneca Pharmaceutical.

"To explore this hypothesis, Han Wistar rats were dosed for up to 5 days with 10-100 mcmol/kg b.i.d. gamma-Sec-I from three chemical series that inhibit Notch processing in...

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Source: Proteomics Weekly (2005-01-03)

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