Alzheimer Disease

Electrophoresis used to study aggregation of beta-amyloid 1-42 and 1-40 peptides

Published in Proteomics Weekly, January 3rd, 2005

Researchers from Italy have reported on the use of capillary electrophoresis in the investigation of the aggregation process of beta-amyloid 1-42 and 1-40 peptides.

"The possibility to monitor, in solution, the steps of beta-amyloid (Abeta) nucleation and therefore to describe this dynamic process by using capillary electrophoresis and under optimized experimental conditions is described," S. Sabella and colleagues, University of Pavia reported.

"Striking differences in the electrophoretic patterns of Abeta 1-42 and Abeta 1-40 over time are shown here, and different aggregation states are elucidated, which reflect the very diverse oligomerization...

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Source: Proteomics Weekly (2005-01-03)

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