Alzheimer Disease
Reactivity to beta-amyloid analyzed, modulation revealed
Published in Proteomics Weekly, January 3rd, 2005
"The brains of Alzheimer's disease patients present activated glial cells, amyloid plaques and dystrophic neurites. The core of amyloid plaques is composed of aggregated amyloid peptide, a peptide known to activate glial cells and to have neurotoxic effects. We evaluated the capability of glial cells to mediate Abeta(1-42) cytotoxicity in hippocampal cultures," wrote R. von Bernhardi and colleagues, Pontificia Universidad Catolica de Chile.
"Conditioned media obtained from microglial cultures exposed to Abeta induced...
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Source: Proteomics Weekly (2005-01-03)
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