Diabetes Pathogenesis
Early T cell development deranged in immunodeficient nonobese diabetic mice
Published in Proteomics Weekly, January 3rd, 2005
According to recent research published in the Journal of Immunology, "NOD mice exhibit defects in T cell functions that have been postulated to contribute to diabetes susceptibility in this strain. However, early T cell development in NOD mice has been largely unexplored. NOD mice with the scid mutation and Rag1 deficiency were analyzed for pre-T cell development in the NOD genetic background. These strains reveal an age-dependent, programmed breakdown in beta selection checkpoint enforcement."
"At 5 to 8 weeks of age, even in the absence of TCRbeta...
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Source: Proteomics Weekly (2005-01-03)
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