Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . January 31st, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
Dopamine Receptors - Protein kinase C mediates behavior and trafficking of the D-2 dopamine receptor
Interferon - Binding of p300 studied, role of N-terminus and protein homologies revealed
Protein Kinase - Fasudil contraction studied, protein kinase C-mediated contraction revealed
Proteinase - Lactobacillus casei intracellular proteinase purified and analyzed
Proteomics - Design and packing interactions of hydrophobic helical hairpins studied
Acidosis - Tyrosine phosphorylation involves acidosis and Ca2+ aortic channels
Adenosine - G-protein activity during prolonged wakefulness influenced by a receptor
Adenovirus - Adenovirus protein E4orf6 interaction mediated by BC-box motif
Adenovirus & Coxsackievirus - Coxsackievirus/adenovirus receptor interacts with MUPP-1 within tight junction
Aging - Life shortening in two fly models studied, role of oxidative stress revealed
Aging - Nuclear proteins in muscle satellite cells analyzed, increase with age revealed
Allergy & Immunology - A site for sore eyes: New target for allergies found under the eyelid
Allergy Medicine - What makes an allergen an allergen?
Alzheimer Disease - Adenovirus vectors encoding A-beta and GM-CSF reduces amyloid load in brain
Alzheimer Disease - Amyloid beta-protein and plaques reduced by neuronal adaptor protein beta
Alzheimer Disease - Destabilization of beta-amyloid fibrils analyzed, role of tannic acid revealed
Alzheimer Disease - Protective effect of moderate drinking against Alzheimer dementia studied.
Alzheimer Disease - Recent findings in Alzheimer disease described
Alzheimer Disease - Recent findings in Alzheimer disease provide new insights
Amyotrophic Lateral Sclerosis - Neurotrophic factor protects SOD1 toxicity in amyotrophic lateral sclerosis
Animal Models - Novel assay facilitates diagnosis of murine Helicobacter bilis infection
Anthrax Vaccines - Studies advance knowledge in anthrax vaccines research
Antibiotic Resistance - Diazepam studied, influence on efflux, porin synthesis Mar phenotype revealed
Antibiotics - Activity of a new cephalosporin against Staphylococcus aureus revealed
Antimicrobial Resistance - Temporal antimicrobial resistance in Staphylococcus spp. in Spain revealed
Antimicrobials - Link between beta-defensin tertiary structure and antimicrobial activity
Antimicrobials - Study defined structure of platelet microbicidal protein-1 and examined activity
Apoptosis - Adhesion kinase-overexpressing cells analyzed, apoptosis resistance revealed
Apoptosis - Apoptosis induced in regenerating liver after partial hepatectomy
Apoptosis - Drosophila RNA-binding protein Lark studied, role in oogenesis revealed
Apoptosis - Drosophila cytochrome C species studied, non-critical requirements revealed
Apoptosis - Tunicamycin-induced apoptosis studied, protective effect of nicotine revealed
Aquaporin - Aquaporin hypertonic induction analyzed, influential roles revealed
Atherosclerosis - Atherosclerosis prevention studied, influence of seawaters revealed
Atherosclerosis - PPAR ligands in atherosclerosis reviewed
Bacterial Pathogenesis - Bacteria binding by DMBT1/SAG/gp-340 confined to VEVLXXXXW motif in CRCR domains
Bacteriology - Bacterial muramyl dipeptide activates NALP3/cryopyrin inflammasome
Bacteriology - Thioredoxin reductase alters cytolytic activity of antibacterial peptide
Bacteriology - Transposon mutants and essential genes mapped in Helicobacter pylori
Bioengineering - Matrix-embedded marrow stromal cells provide long-term protein expression
Biotechnology - Respiration in a bioengineered Saccharomyces cerevisiae revealed
Bipolar Disorder - Leptin secretion and mRNA levels in adipocytes influenced by valproic acid
Bone - Testosterone boosts osteoprotegerin mRNA expression in mouse osteoblast cells
Bone Marrow Transplantation - IL-18 has paradoxical effects on CD4 and CD8 cell-mediated GVHD
Bovine Spongiform Encephalopathy - Histopathology of bovine spongiform encephalopathy affected by clusterin
Breast Cancer - Ectopic IRF-1 expression promotes tumor cell death
Breast Cancer - Gene vaccine protects mice against development of Her2/neu breast cancer
Breast Cancer - Loss of ERalpha signaling induces epigenetic silencing of downstream targets
Breast Cancer Vaccine - Vaccine against epidermal growth factor receptor useful for breast cancer
Brucellosis - Cytokines and nitric oxide elevated in patients with brucellosis
Business Update - BioSciences company announces research collaboration with Pfizer
Business Update - Pharma companies sign development agreement for proteins
CHARGE Syndrome - Scientists crack part of "histone" code
Cancer Therapy - Can plant research lead to new insights in cancer research?
Cancer Therapy - Company commences clinical trials of Panzem NCD in patients with advanced cancer
Cancer Therapy - Dacogen NDA accepted for filing by U.S. FDA
Cancer Therapy - Ellipticine metabolites responsible for DNA binding identified
Cancer Therapy - Pharma company enters research and development agreement with cancer institute
Cancer Therapy - Snm1 deficiency abolishes early spindle stress-induced mitotic checkpoint
Cancer Therapy - Therapy directed against Bcl-2 helps rituximab limit lymphoma growth
Cancer Vaccine - IL-2-binding cytokines affect costimulatory properties of leukemia cells
Cancer Vaccine - Link between insulin receptor and epidermal growth factor receptors reviewed
Cancer Vaccines - Researchers describe findings in cancer vaccines studies
Candidiasis - Peptide inhibits adherence of Candida albicans
Cardiology - 6-Hydroxydopamine effect on Na+/Ca2+ exchanger gene expression studied
Cardiology - Aldosterone stimulates cardiac fibroblasts to produce and secrete adrenomedullin
Cardiology - GATA4 was shown to be a potent regulator of cardiac gene activity
Cardiology - Heart Mb gene expression is influenced by thyroid status
Cardiology - Hhex expression is essential for normal cardiovascular development
Cardiology - Human endothelial cells express neuronal nitric oxide synthase
Cardiology - Phosphorylation of calsequestrin on CK2-sensitive sites in heart characterized
Cardiology - Recent findings illuminate research in cardiology
Cardiology - Retinal glutamate transporter studied, persistance in ischemia revealed
Cardiology - TNF-alpha can differentially regulate cardiac connexin
Cardiomyocites - Salusins may be regulatory factors for myocardial growth and hypertrophy
Cardiovascular Research - Long-term administration of stress-related peptides had prolonged CV actions
Cell Biology - Chromosomes make a DASH for stability
Cell Biology - Novel monoclonal antibody identifies M-phase cells
Cell Biology - Plk1 polo-box motif targets the centrosome regulator RanGTPase
Cell Biology - Researcher answers fundamental question of cell death
Cell Biology - Scientists find a "Morse code" for human cells
Cell Movement - Chemotaxis analyzed, role of localized Ras signaling revealed
Cell Signaling - Myeloid cell GPI-anchor deficiency causes impaired Fc gamma R effector functions
Cell Signaling - Recombinant murine Wnt-1 induces intracellular signaling of Wnt pathway
Cell Signaling - Two interacting kinases studied, putative role as Rap2 effectors revealed
Cervical Cancer - Increased PAI-1 expression correlated with worse survival, relapse
Chemotherapy - Synergy between BCNU and didox circumvents DNA repair in glioma
Chlamydiosis - Ovine live vaccine protects against Chlamydophila abortus-related abortion
Cholesterol - LXR activation and cholesterol efflux studied, lipoprotein depot implicated
Cholic Acid - Crystal structure of fatty acid-binding protein and cholic acid complex revealed
Colon Cancer - Chemopreventive effect of fish oil may be due to direct action of n-3 PUFA
Colorectal Cancer - Predictors of response to oxaliplatin identified
Contraception - Studies add new findings to contraception body of knowledge
Cytomegalovirus - Genetic polymorphisms among cytomegalovirus wild-type strains reported
DNA Research - DNA-binding agents make plasmid DNA transfection more efficient
Dementia - Alpha-synuclein isoforms studied, differential expression in dementia revealed
Dendritic Cell Vaccine - Dendritic cell vaccines may prevent fungal infections
Dengue Fever - Chimpanzee Fab fragments and IgG cross-neutralize dengue viruses
Dermatology - Differentially expressed genes in proliferating keratinocytes identified
Development - Plakoglobin shifts from adherens junctions to desmosomes as heart develops
Developmental Biology - Cell lineage made simple
Developmental Biology - Molecular pathway turns a juvenile heart into an adult heart
Developmental Biology - Mouse zinc transporter 1 gene regulates maternal zinc delivery to embryo
Diabetes Pathogenesis - Arginine vasopressin plays role in diabetic increase in glucagon secretion
Diabetes Pathogenesis - Findings advance knowledge in diabetes pathogenesis research
Diabetes Pathogenesis - Genes and pathophysiology of type 2 diabetes reviewed
Diabetes Pathogenesis - Inhibition of islet amyloid polypeptide fibril formation investigated
Diabetes Pathogenesis - Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids
Diabetes Pathogenesis - Recent findings in diabetes pathogenesis provide new insights
Diabetes Pathogenesis - Reports advance knowledge in diabetes pathogenesis research
Diabetes Pathogenesis - Role of renin-angiotensin-aldosterone system in diabetes examined
Diabetes Pathogenesis - Type 1 diabetes duration not linked to glutamic acid decarboxylase antibodies
Diabetes Research - Induced platelet aggregation studied, effect of orthovanadate revealed
Diabetes Risk Factors - Beta-cell autoimmunity not increased in twins of type 1 diabetic patients
Diabetes Therapy - Findings describe new data in diabetes therapy research
Diabetes Therapy - Inhibition of adhesion molecules generates resistance to type 1 diabetes
Diabetes Therapy - Researchers' data advance diabetes therapy research
Diabetes Therapy - Studies add new findings to diabetes therapy body of knowledge
Diabetes Therapy - Thiazolidinedione derivatives with antihyperglycemic activity synthesized
Diabetic Nephropathy - Connective tissue growth factor mediates glucose effect on matrix degradation
Diabetic Nephropathy - Long-term inhibition of neuronal nitric oxide synthase is nephroprotective
Diabetic Nephropathy - New findings in the area of diabetic nephropathy described
Diabetic Neuropathy - Diabetic gene expression established before neuroaxonal dystrophy
Diagnostics - Novel confirmatory serodiagnostic test developed
Diagnostics - Target-capture polymerase chain reaction measures hepatitis B load accurately
Diagnostics - Tests for clinical features of APS compared
Diet & Nutrition - Cereal applauds new U.S. Dietary Guidelines
Disease Associations - Arx polyalanine increase modulates intranuclear inclusions and cell death
Disease Associations - Link between joint degeneration biomarkers and cartilage appearance examined
Dopamine Receptors - Agonism at D-2 dopamine receptors studied, influence of G protein revealed
Down Syndrome - S100B level in amniotic fluid isn't reliable alone as biomarker
Drug Abuse - Study sheds light on biology behind cocaine cravings
Drug Delivery - High-affinity antibody steers therapy to hepatocellular carcinoma
Drug Delivery - Nucleoside transporter expression often reduced or lost in gynecologic tumors
Drug Delivery - Utility of polyanhydride microspheres for protein delivery evaluated
Drug Development - Chimpanzee shows promise as pharmacokinetic model for human drugs
Drug Development - Effect of site-specific pegylation on abciximab efficacy determined
Drug Development - Expression of human P450s characterized in mice with humanized liver
Drug Development - Mass spectrometry integrated into membrane protein drug discovery
Drug Development - Novel VIP analogue may facilitate asthma drug delivery
Drug Development - Parthenolide has microtubule-interfering activity
Drug Development - Phase IIa trial of antisense drug for multiple sclerosis initiated
Drug Development - Regimens combining antisense molecules with other drugs optimize outcomes
Drug Development - Schisandra fruit extract contains potent CYP3A4 inhibitors
Drug Metabolism - Contribution of CYP3A5 to hepatic drug metabolism elucidated
Drug Metabolism - Inhibitory effects of nitric oxide on P450 enzymes characterized
Drug Metabolism - Novel fluorescent probe measures CYP3A activity in cultured hepatocytes
Drug Metabolism - Recombinant enzyme kinetics useful in prediction of human clearance
Drug Metabolism - Urinary metabolites of zonampanel monohydrate characterized in rats
Drug Resistance - Helicobacter pylori metronidazole resistance influenced by reductases
Drug Resistance - Cephalosporinase variants detected in a Proteus mirabilis clone
Drug Therapy - Activity of novel macrolides againstHaemophilus influenzae revealed
Drug Treatment - Endocannabinoid signaling studied, negatively modulation revealed
Drug Treatment - Neuron kinase activation studied, antidepressant role revealed
Embryonic Stem Cell Research - mTOR gene disruption prohibits embryonic stem cell development
Endocrinology - Estrogen up-regulates hepatic expression of cytokine signaling suppressors
Endocrinology - Findings advance knowledge in endocrinology research
Endocrinology - Researchers describe findings in endocrinology studies
Endocrinology - Transcriptional regulation of agouti-related protein described
Environmental Health - Pollutants adversely affect nerve cell development in clam embryos
Enzymology - Aging studied, skeletal muscle nonenzymatic and proteasome influences revealed
Enzymology - Alpha-zein analyzed, effects of glutaminase deamination revealed
Enzymology - Design strategies for protein kinase inhibitors presented
Enzymology - Glycogen synthase kinase-3 in insulin and Wnt signalling reviewed
Enzymology - Hepatitis B virus reverse transcriptase requires heat shock protein to function
Enzymology - Methylthioadenosine phosphorylase gene expression falters in liver disorders
Enzymology - Phenylalanine hydroxylase studied, possible role in oxidation revealed
Enzymology - Studies add new findings to enzymology body of knowledge
Escherichia Coli Vaccine - Distribution of adhesins in Shiga toxin-producing E. coli reported
Exercise - Reports describe recent advances in exercise research
Factor XI - Factor XI studied, interaction with regions of glycoprotein Ib alpha revealed
Finance - Searle grant funds proteomics initiative
Food-Borne Illness - Karenia brevis exposure eliminates brevetoxin metabolism in oysters
Garlic - Organosulfur compounds in garlic may alter chemotherapeutic treatments
Gastric Cancer - Studies describe new findings in gastric cancer research
Gastroenterology - Stabilized lipoplexes accelerate DNA release in liver cells
Gene Expression - Robust peptide nucleic acid distribution would improve their efficacy
Gene Research - Expression of CAPA gene was determined by in situ hybridization techniques
Gene Transfer - Phi C31 integrase and nucleofection create stable transgene expression
Genetic Disorders - Tcof1-associated gene expression characterized in mouse neuroblastoma cells
Genistein - Genistein studied, reduction of arterial smooth muscle contractions revealed
Genistein - Genistein-induced inhbition of tyrosine kinase decreases neuron excitability
Genomics - New findings in the area of genomics detailed
Geriatrics - Growth hormone upregulates a protein that gives humans muscle strength
Glutamate Receptors - Calmodulin binding to metabotropic glutamate receptors determined
HIV/AIDS Pathogenesis - Glutamine-rich region of HIV-1 Tat is involved in T-cell apoptosis
HIV/AIDS Research - Cellular cofactors for HIV replication identified via ribozyme-based genomics
HIV/AIDS Therapy - DL-amino acid-containing fusion peptide inhibits cell-cell fusion
HIV/AIDS Therapy - Fast track status granted for PA-457, a maturation inhibitor
HIV/AIDS Therapy - T-1249 efficiency related to ability to insert/adsorb to lipidic bilayers
HIV/AIDS Vaccine - Fc-gammaRI is involved in HIV-1 inhibition by polyclonal IgG
HIV/AIDS Vaccine - HLA-B has dominant influence in mediating co-evolution of HIV and HLA
HIV/AIDS Vaccine - Neutralization analysis of anti-HIV monoclonal antibodies conducted
HIV/AIDS Vaccine - Outer domain of the gp120 glycoprotein from HIV-1 characterized
HIV/AIDS Vaccine - Variation in dominant epitope affects neutralization of HIV Tat protein
Head and Neck Cancer - Research add new data to head and neck cancer body of knowledge
Heat Shock Protein - Leukocyte heat shock protein expression studied, effect of age revealed
Hematology - Aberrant hypermethylation associates with gene silencing in Burkitt lymphoma
Hepatitis B Virus - Long-term outcomes after HBV seroconversion compare in Ba and C type infections
Hepatitis C Virus - Protein kinase C affects the way interferon treats hepatitis C infection
Herpesvirus - Reports describe recent advances in herpesvirus research
Hormone Replacement Therapy - Progesterone increases NO synthesis, potentiates estradiol, unlike MPA
Huntington Disease - Nitropropionic acid toxicity analyzed, cannabinoid receptors implicated
Immunology - 4-1BB and OX40 independently facilitate robust CD8 and CD4 recall responses
Immunology - Adaptive immune responses to soluble proteins shaped by TLR agonists
Immunology - Bystander suppression occurs despite normal clonal expansion of T cells
Immunology - Findings advance knowledge in immunology research
Immunology - Gene expression during naive CD4 cell activation characterized
Immunology - Peptide induces antibodies reacting with thyroglobulin and thyroid peroxidase
Immunology - Researchers publish new studies and findings in the area of immunology
Infections - Plasmodium vivax erythrocyte binding studied, ligand residues revealed
Infections - Pseudomonas aeruginosa phenotpes change during cystic fibrosis infection
Infections - Staphylococcus aureus inhibition of keratinocyte migration revealed
Infections - Xenorhabdus nematophila tripartite infection analyzed, stages revealed
Infections - N-glycan glucosidase system in Trypanosoma brucei studied and clarified
Inflammation - Neurogenic inflammation analyzed, role of specific action potential revealed
Inflammation - P2X3 /P2X2/3 receptor antagonist reverses inflammatory hyperalgesia
Influenza Vaccines - Neuraminidase activity assays for monitoring influenza virus described
Information Technology - Company launches server to accelerate collaboration in life sciences R&D
Information Technology - Expanded version of protein classification system database released
Insulin Resistance - Researchers' work adds to insulin resistance body of knowledge
Laboratory Methods - "Nanoshells" enhance sensitivity to chemical detection by factor of 10 billion
Leishmaniasis - Proteins secreted from salivary glands of Leishmania vector identified
Leptin Studies - IL-11 affects plasma leptin levels in inflamed and non-inflamed rabbits
Leukemia - Antisense molecules targeting Wilms tumor gene exon 5 may treat cancer
Liver Cancer - Occult hepatitis B virus is the cause of some hepatocellular carcinomas
Liver Cancer - The carboxy-terminus of hepatitis B virus X protein triggers angiogenic protein
Liver Disease - China Human Proteome Organization completes installation for HLPP research
Lyme Disease - ospC diversity in Borrelia burgdorferi explored
Malaria - Evidence found for VAR2CSA involvement in pregnancy-associated malaria
Malaria - Malarial sporozoites studied, role of membrane skeletal protein revealed
Malaria - SICAvar switching event in Plasmodium linked to DNA rearrangement
Malaria - Virulence proteins studied, host-targeting signal reveals malarial secretome
Malaria Vaccine - Malaria parasite-inhibitory antibody epitopes merozoite protein mapped
Malaria Vaccines - New data illuminates research in malaria vaccines
Malaria Vaccines - Recent findings illuminate research in malaria vaccines
Malaria Vaccines - Research in malaria vaccines provides new insights
Malaria Vaccines - Researchers provide details of new studies and findings in the area of malaria vaccines
Malaria Vaccines - Researchers publish new studies and findings in the area of malaria vaccines
Meningitis Vaccine - Distribution of Neisseria serogroups and genotypes reported
Mergers & Acquisitions - Research products company buys molecular discovery software firm Optive Research
Metapneumovirus Vaccine - Metapneumovirus lacking G glycoprotein yields promising vaccine candidate
Molecular Biology - Scientists reveal molecular secrets of the malaria parasite
Multiple Myeloma - Early paraprotein response identifies high risk multiple myeloma patients
Myocardial Infarction - Positive results announced from clinical trial of arterial inflammation drug
Myocardial Ischemia - Antidigoxin antiserum reduces apoptosis after myocardial I/R in rats
Myosins - Motility studied in chimeric Chara myosins, role of converter region revealed
Neuraminidase - Bacterial neuraminidase studied, role of aspartic acid in catalysis revealed
Neuroblast Development - Drosophila neuroblasts studied, needs for inscuteable mRNA positioning revealed
Neurology - Aquaporin-4 expression is elevated in sclerotic hippocampi
Neurology - Aspects of Drosophila nervous system developmental architecture revealed
Neurology - Axonal outgrowth of ganglia reduced upon inhibition of c-Jun phosphorylation
Neurology - Intracellular, cell excitability studied in rat cortical neuron model
Neurology - Receptor diffusion in neurons studied, role of actin and a protein revealed
Neurology - Sox6 is essential for neuronal differentiation
Neurology - Zebrafish telencephalon analyzed, receptor-dependent potentiation revealed
Neuroscience - New findings in the area of neuroscience described
Neuroscience - Presenilin-I may direct glial-specific gene expression
Neurotransmission - Vesicular glutamate transporters studied, widespread corelease revealed
Nitric Oxide - Endothelium-dependent relaxation of aorta induced by marine algal lectin
Nociceptin - Nociceptin studied, molecular mechanisms of calcium current modulation revealed
Nucleoside Transporters - Nucleoside transporters studied, long-term endocrine regulation revealed
Nutrition - Aromatic amino acids improve leucine kinetics in sick and malnourished infants
Nutrition - Effects of vitamins C and E on oxidative stress in rat Sertoli cells revealed
Nutrition - Fatty acids of milk fat studied, release by lipase and psychrotrophs revealed
Obesity Genomics and Genetics - Gene fad104 has significant role in adipogenesis
Obesity Pathogenesis - Hypothalamo-pituitary-thyroid axis abnormal in obese mice
Obesity Pathogenesis - Protein directly promotes lipogenic enzyme gene transcription
Obesity Pathogenesis - Reports add new data to obesity pathogenesis research
Oncogenesis - Surprising study reveals how cancer-causing protein activates
Oncology - EGR1 transactivation plays role in mutant p53 gain of function
Oncology - AKT activation is early event in lung tumorigenesis
Oncology - Androgen regulation of tumor-related gene expression characterized
Oncology - BMP antagonist noggin upregulated in BMP-6+ prostate tumors
Oncology - Histone deacetylase inhibitor FR901228 defeats lung cancer cells
Oncology - Id1 helix-loop-helix protein overexpression is prominent in gastric cancers
Oncology - Researchers publish new studies and findings in the area of oncology
Oncology - Transcription factor expression characterized in clinical tumor samples
Oncology - Tumor necrosis factor receptor p55 maintains tumor neovascularization
Oncology - Uncleavable pro-scatter factor obstructs tumor growth and dissemination
Opioid Receptors - Effects of interferon-alpha on cloned opioid receptors analyzed in oocytes
Overactive Bladder - Darifenacin meets the need for an effective overactive bladder pharmacotherapy
Pain Medicine - Chronic morphine treatment alters cytoskeletal proteins in rat striatum
Pancreatic Fibrosis - Pressure activates pancreatic stellate cells
Parkinson Disease - Genetic therapeutic targets identified in substantia nigra pars compacta
Peptide Receptor - Assay will be useful in studies to characterize UT receptor ligands in vivo
Peptide Signal - Protein carboxyl methylation reaction may play a role in signaling reactions
Peptides - MinK-related peptides may have a prominent role in channel dependent systems
Personnel - David Ichikawa named senior VP, business development, by DNA-focused company
Personnel - Genetics company names chief medical officer and chief science officer
Personnel - Michael Treble appointed CEO of pharmaceutical company's Ibis program
Pertussis Vaccine - Antigen targeting to CD11b allows in vivo Th1-polarized T-cell priming
Pertussis Vaccine - Polymorphisms of fimbria fim3 gene of Bordetella pertussis isolated
Physiology - Caenorhabditis elegans stress survival studied, role of a protein revealed
Physiology - Cochlear function in Prestin knockout mice analyzed
Physiology - Hepatocyte heat shock genes studied, regulation in an Antarctic fish revealed
Physiology - Induced increase in intracellular Ca2+ in neutrophils can be blocked
Physiology - Modulation of the potentiation induced by Ca2+ channel activation revealed
Physiology - Nogo66 studied, cholestrol-mediated segregation and signaling clarified
Physiology - Rab proteins analyzed, role of phosphatidylinositol kinase subunit revealed
Physiology - Specific cotransporter studied, modulation of diffusion and activity revealed
Physiology - Stress response studied, specific protein interactions observed
Plasminogen - Tissue-type plasminogen activator studied, regulation of availability revealed
Polio Vaccines - Research in polio vaccines provides new insights
Prions - Amyloid prion aggregates analyzed, destabilization conditions revealed
Probiotics - Dairy yeast strains screened for probiotic applications
Professional Education - Library launches three new open-access journals
Progenitor Cells - Increased transcription factor expression identifies reactive progenitor cells
Progenitor Cells - Potassium channel subunits studied, role in progenitor proliferation revealed
Protein Kinase - Amino-terminal domain of a kinase-reactive protein important for relocation
Protein Kinase - Protein kinase analyzed, role in intestinal neuron excitation revealed
Protein Processing - Study investigated the mechanism by which soy intake reduces cholesterol levels
Protein Signaling - Monoclonal antibodies against SETA/CIN85/Ruk isoforms characterized
Proteolysis - Degradation of gluconeogenic enzymes studied, distinct mediations revealed
Proteomics - Ciliary protein phosphorylation regulated by Ca2+ and nitric oxide
Proteomics - Cyclic AMP protects endothelial barriers by blocking Rac-1 inhibition
Proteomics - New data illuminates research in proteomics
Proteomics - Novel essential chromodomain protein identified
Proteomics - Recent findings illuminate research in proteomics
Proteomics - Recent studies add new data to proteomics research
Proteomics - Role of O-GlcNAc glycosylation during Xenopus oocyte maturation clarified
Proteomics - Substrate interaction and voltage dependency of Na+/P-i cotransporter reported
Proteomics - Vanilloid receptor TRPV1 has Ca2+-sensitive tubulin interaction
Prothrombin - Specific residues contribute to factor Va binding in prothrombinase complex
Pulmonary Fibrosis - Bleomycin-induced lung fibrosis influenced by aminoguanidine and erdosteine
Pulmonary Hypertension - Endothelin antagonists have potential for cardiovascular disorders
Pulmonary Hypertension - Sitaxsentan used for treatment of pulmonary hypertension
Receptor Studies - Selective estrogen receptor modulators in desmoid tumors reviewed
Renal Cell Carcinoma - Select glucocorticoids reduce the metastatic potential of renal cancer
Reproductive Biology - GATA-4 and GATA-6 distribution in rat fetal gonad and postnatal ovary studied
Reproductive Medicine - Cytoplasmic asters needed for cell cycle progression in cloned mouse embryos
Reproductive Medicine - Effect of cryopreservation and thawing on sperm apoptosis determined
Respiratory Medicine - Angiogenic proteins tie vessel alteration to congenital diaphragmatic hernias
Respiratory Syncytial Virus - Bovine respiratory syncytial virus infection affects adhesion of neutrophils
Retinopathy of Prematurity - Oxygen thresholds may sway oxygen-induced retinopathy in premature infants
Rheumatoid Arthritis - Very early treatment of rheumatoid arthritis offers sustained benefits
SARS Vaccine - Antigenic sites on nucleocapsid protein of SARS coronavirus mapped
SARS Vaccines - New findings in the area of SARS vaccines described
SARS Vaccines - New research in the area of SARS vaccines detailed
Schistosomiasis - Schistosoma mansoni soluble proteome compared across life-cycle stages
Sickle Cell Disease - Endothelial P-selectin contributes to microcirculatory abnormalities in vivo
Sildenafil - Sildenafil analyzed, stimulation of serotonin transport revealed
Smooth Muscles - Rho-kinase inhibition and coupling in ureter smooth muscle clarified
Spinal Cord Injury - Motor neurons produce angiogenic protein after sciatic nerve crush injury
Stem Cell Research - BMP-2 silk fibroin films induce BM stromal cell osteogenic differentiation
Stem Cell Research - Thrombospondin-4 C-terminal peptide stimulates erythroid cell proliferation
Stroke - Iroxanadine may help reduce blood vessel damage in heart attack and stroke
Surgical Technology - Vascular response to angiotensin II predicts long-term outcome
Thalassemia - Hemoglobin-stabilizing protein role in erythropoiesis and thalassemia revealed
Toxicology - Mactra chinensis shellfish toxin transforming enzyme purified and analyzed
Transplant Medicine - Blood pressure control in kidney transplantation has therapeutic implications
Tularemia Vaccine - Transposon-transposase complexes create mutants of Francisella tularensis
Tumor Suppression - ARF impedes NPM/B23 shuttling in Mdm2-sensitive tumor suppressor pathway
Vaccine Adjuvant - Adjuvant based on proteoliposome-derived cochleate structure developed
Varicella-Zoster Virus - Varicella-zoster studied, differing needs in pathogenesis revealed
Vascular Disease - Results of gene-transfer approach to vascular disease using stents published
Vasopressin - Hemodynamic effects of vasopressin analogues studied, comparison reported
Vector Development - Bacmid to improve integrity of secreted recombinant proteins developed
Virology - Hepatitis C virus E1 and E2 glycoproteins have separable functional properties
Virology - New findings in the area of virology detailed
Virology - Raf makes VEGF amplify Kaposi sarcoma-associated herpevirus infection
Virology - Small chimeric intron sequences favor adenovirus-mediated gene transfer
Virology - Studies add new findings to virology body of knowledge
Virology - The NS5A protein of hepatitis C virus coordinates zinc
Wilson Disease - ATP7B gene expression mitigates abnormal copper metabolism in rodent livers
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