Proteomics Weekly

Alzheimer Disease - Amyloid accumulation analyzed, related protein profiled

Central Nervous System - ADAM23 analyzed, role as neuron cell-surface glycoprotein revealed

Phosphatase - Hippocampal neurons studied, role of calcium entry in kinase signaling revealed

Proteomics - Drosophila training of pheromonal cues enhanced by a protein kinase

Proteomics - Researchers describe findings in proteomics studies

Reproductive Medicine - Researchers' work adds to reproductive medicine body of knowledge

Toxins - Botulinum neurotoxin studied, mapping of synaptosome-binding regions reported

Acute Lung Injury - Transcriptional effects of LPS-induced ALI characterized

Acute Myelogenous Leukemia 1 - Hematopoietic potential of AML1 closely related to its transcriptional activity

Adenosine Receptor - G protein activation studied, evidence for agonist-specific reaction revealed

Adipose Tissue - Oxidative capacity differences of adipose tissue linked to mitochondria

Adverse Drug Reaction - Selective COX-2 inhibitor rofecoxib delays gastric ulcer healing

Alcohol Use - Oxidized mitochondrial proteins identified in alcohol-exposed cells

Allergy & Immunology - Down-regulated STAT6 curtails acute and chronic contact hypersensitivity

Alzheimer Disease - Alzheimer disease studied, allele-specific overexpression in astrocytes shown

Alzheimer Disease - Amyloid precursor protein analyzed, new transmembrane cleavage site identified

Alzheimer Disease - Anti-A-beta antibody injection into third ventricle reduces amyloid plaques

Alzheimer Disease - Findings in Alzheimer disease provide new insights

Alzheimer Disease - Intracellular Abeta 42 studied, activation of p53 promoter revealed

Alzheimer Disease - Oxidative stress in organs studies, role of aluminum-maltolate complex clarified

Alzheimer Disease - Peptide chaperone studied, role in amyloid fibrillogenesis and toxicity revealed

Alzheimer Disease - Researchers detail new studies and findings in the area of Alzheimer disease

Amyotrophic Lateral Sclerosis - GLT-1 glial glutamate transporter studied, ALS-associated changes clarified

Amyotrophic Lateral Sclerosis - Researchers publish new studies and findings in the area of amyotrophic lateral sclerosis

Angioplasty - Rapamycin foils restenosis by blocking leukocytes and precursor cells

Angiotensin - Angiotensin II receptor studied, effect of domain mutagenesis reported

Anthrax - Anthrax toxin channels analyzed, role in protein translocation revealed

Anthrax Vaccine - Protein fusion enhances immunogenicity of anthrax protective antigen

Antibacterial Activity - Amphiphilic polynorbornene derivatives studied, role of hydrophobicity clarifed

Antibiotics -  Terfezia claveryi aqueous peptide extract inhibits Staphylococcus aureus

Apoptosis - Beta-amyloid-induced astroglioma apoptosis studied, role of melatonin revealed

Apoptosis - Biotech company announces homogeneous caspase 8 & 9 assays for life science labs

Apoptosis - P-selectin glycoprotein ligand-1 cross-linking induces activated T cell death

Arachidonic Acid - Arachidonic acid role in transglutaminase and stress fiber formation revealed

Astrocytes - Prion protein studied, pathology in brain and retinal cells revealed

Atherosclerosis - Effects of TNF-alpha and/or alpha lipoic acid on VSMCs characterized

Atherosclerosis - Hyperlipidemia and hyperglycemia stimulate atherosclerotic macrophages

Atherosclerosis - Late-stage atherosclerosis analyzed, role of reduced cGMP signaling revealed

Atherosclerosis - PPAR alpha, beta/delta, and beta studied, inhibition features identified

Atherosclerosis - Researchers' work adds to atherosclerosis body of knowledge

Atherosclerosis - Review describes effects of endotoxin that may be relevant to atherosclerosis

Biomarker Discovery - Genomics company details versatility of protein labeling technology

Biomedical Engineering - Ex vivo models define enzymes essential to neovascularization

Biomedical Engineering - Programmable DNA microchips offer multiplex gene synthesis

Biotechnology - Recombinant spider dragline silk proteins studied, novel assembly shown

Bioterrorism - Multipathogen oligonucleotide microarray developed

Brain Cancer - Protein stops growth of brain tumor

Breast Cancer - ADAM 12 cleaves extracellular matrix proteins, correlates with cancer status

Breast Cancer - MIB1 index useful as marker of chemotherapy response

Breast Cancer Therapy - Trastuzumab and geldanamycin have different effects on ErbB2

Bronchopulmonary Dysplasia - Neonatal alveologenesis studied, influence of oxygen and neutrophils revealed

Business Update - BeadLab to be installed at Mayo Clinic's Rochester, Minnesota, location

Business Update - Genomics-focused company celebrates 10 years with new labs, equipment, IT

Business Update - German genomics center partners to distribute products in Japan, N. America

Business Update - MetaDrug V1.0 launched

Cancer Therapy - Inhibition of kinesin spindle protein by monastrol characterized

Cancer Therapy - Research sheds light on how cancer cells become resistant to treatment

Cancer Treatment - Zalypsis for solid tumors enters clinical development

Cancer Vaccine - Gangliosides and glycoproteins are receptors for the anticancer drug rViscumin

Cancer Vaccine - Gene expression after polysaccharide-K therapy in colon cancer cells reported

Cancer Vaccine - Soluble tumor-associated antigens have antitumor effect on mammary tumors

Cancer Vaccines - Data advance knowledge in cancer vaccines research

Cancer Vaccines - Recent studies add new data to cancer vaccines research

Cancer Vaccines - Research add new data to cancer vaccines body of knowledge

Cardiology - Study examined the myocardial substrates of protein kinase D

Cardiomyocytes - Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter cell cycle

Cardiomyocytes - Nonhematopoietic MSC can mobilize/differentiate into cardiomyocytes after MI

Cardiovascular Research - Interaction may control the vascular redox state in various CV diseases

Cardiovascular Research - Results suggest molecular link between cellular injury and inflammatory response

Cardiovascular Research - The FSAP511E allele exacerbates atherosclerosis or its clinical sequelae

Cell Biology -  Xenopus APC associates with microtubule-destabilizing protein XMCAK

Cell Biology -  Xenopus TPX2 domains involved in microtubule nucleation characterized

Cell Biology - Adipocyte microtubule stabilization inhibits nuclear translocation of STATs

Cell Biology - Crystal structure of spindle assembly checkpoint protein Bub3 determined

Cell Biology - Lack of enzyme turns fat cells into fat burners

Cell Biology - Novel laser system facilitates controlled microtubule ablation

Cell Biology - Priming embryonic stem cells to fulfill their promise

Cell Biology - Short tetracysteine tags to beta-tubulin show promise for live cell imaging

Cell Death - Bcl-2 proteins studied, role in non-apoptotic cell death revealed

Cervical Cancer - Protein may have limited use as biomarker in cervical glandular lesions

Cervical Cancer - Report card on cervical cancer prevention underscores importance of HPV testing

Charcot-Marie-Tooth Disease - Disruption of a phosphatase produces Charcot-Marie-Tooth-like neuropathy

Chemotaxis - Dictyostelium analyzed, essential role of PAKc in chemotaxis revealed

Chlamydia - Dendritic cells regulate inflammatory cytokines upon Chlamydia infection

Chlamydiosis - CPAF is produced and immunogenic during human chlamydial infection

Cholera - Findings advance knowledge in cholera research

Cholesterol - Kir2.1 channels analyzed, cholesterol effect and lipid raft targeting revealed

Collagen - Collagen II analyzed, binding site for discoidin domain receptor revealed

Colon Cancer - DNA research shows promise of next-generation colorectal cancer screening test

Colon Cancer - Dietary lipid hydroperoxides boost the production of proangiogenic protein

Complementary and Alternative Medicine - Green tea polyphenol diminishes the production of cancer-related growth factors

Congestive Heart Failure - Researchers discover new kind of heart failure gene

Cryptorchidism - Human sporadic cryptorchidism analyzed, role of CgRP pathway mutations clarified

Cystic Fibrosis - Research add new data to cystic fibrosis body of knowledge

DNA Research - Novel DNA microarrays facilitate transcription factor analysis

DNA Research - Silicon/silicon dioxide substrate optimizes fluorescence DNA microarray

DNA Vaccine - DNA-encoding chicken IL-6 and E. coli protein stimulate antibodies

Dementia - Fibrillar ABri amyloid analyzed, metal-mediated formation revealed

Dental Research - Dentinal lesions studied, infleuence of multiple lesions on pulp clarified

Dermatology - Host enzymes cooperate to promote the angiogenic phenotype of cancer cells

Diabetes - Dipeptidyl Peptidase-IV inhibitor phase II study initiated

Diabetes Complications - Diabetes enhances apoptosis induced by cerebral ischemia

Diabetes Complications - KGF-1 gene transfer accelerates wound healing in diabetic mice

Diabetes Genomics and Genetics - Point mutation not associated with development of type 1 diabetes

Diabetes Pathogenesis - Characteristics of GAD-antibody-positive patients described

Diabetes Pathogenesis - Diabetic mice exhibit unique patterns of reactivity to islet antigens

Diabetes Pathogenesis - Findings in diabetes pathogenesis provide new insights

Diabetes Pathogenesis - HNF-4 alpha involved in late-onset type 2 diabetes

Diabetes Pathogenesis - Insulitis determines susceptibility of islets to coxsackievirus

Diabetes Pathogenesis - New data illuminates research in diabetes pathogenesis

Diabetes Pathogenesis - New findings in the area of diabetes pathogenesis detailed

Diabetes Pathogenesis - New research in the area of diabetes pathogenesis detailed

Diabetes Pathogenesis - Recent findings illuminate research in diabetes pathogenesis

Diabetes Prevention - Plant protein mimics hormone that mitigates diabetes and obesity

Diabetes Therapy - Structure of GIP fragment determined

Diabetes Therapy - Targeting OX40/OX40 ligand interactions prevents diabetes in late stage

Diabetic Nephropathy - Research in diabetic nephropathy provides new insights

Disease Associations - Chondrocyte studied, comminication in articular cartilage clarified

Disease Associations - Lafora disease studied, saccharide-mediated phosphatase inhibition revealed

Drug Delivery - Heparinized hydrogels sustain VEGF release in laboratory assays

Drug Development - In silico system used to identify sirtuin type 2 inhibitors

Drug Development - Ischemic acute renal injury studied, lipocalin-mediated amelioration revealed

Drug Development - gp91(phox)-containing NADH oxidase is therapeutic target of sepsis

Drug Resistance - Antisense therapy reverses multidrug resistance in cancer cells

Drug Resistance - P-glycoprotein is a target for beating refractory autoimmune diseases

Dystonia - Inclusions in torsion dystonia studied, inhibition by glycosylation revealed

Ebola Virus - Rescue of Ebola virus from cDNA using heterologous support proteins studied

Endocrinology - Interwoven signals bind angiogenesis to thyroid cancer proliferation

Endocrinology - Manserin, a peptide, may exert a specific role in the neuroendocrine system

Endocrinology - Recent studies add new data to endocrinology research

Endocrinology - Studies advance knowledge in endocrinology research

Endocrinology - The Id1 gene regulates the growth of thyroid cancer cells

Endocytosis - Surface growth factor receptors studied, nature of stabilization clarified

Endometrial Cancer - Focal adhesion kinase overexpression characterized in endometrial neoplasia

Endometrial Carcinoma - Alterations in expression of NF-kappaB and related proteins identified

Endometriosis - MMP expression compared among different types of endometriosis

Environmental Health - Genomic effects of diesel exhaust on rat alveolar epithelial cells determined

Enzymology - Quinol:fumarate reductase studied, coupling of proton transfer calculated

Enzymology - Uracil DNA glycosylase uses passive search mechanisms to find uracil in DNA

Epilepsy - Suppression of absence epilepsy seizures depend on balance of proteins

Epilepsy Therapy - Effects of lamotrigine on hippocampal amino acid release determined

Equine Protozoal Myeloencephalitis -  Sarcocystis neurona surface antigen gene evolved under selection pressure

Familial Amyloid Polyneuropathy - Extracellular matrix remodeling genes upregulated in FAP

Fragile X Syndrome - Fragile X syndrome studied, altered stress-induced c-fos expression revealed

Ganglions - Retinal ganglion cell studied, survival and axon regrowth mechanisms revealed

Gender Medicine - Estrogen modulates RGS9 expression in the nucleus accumbens

Gene Profiles - Chronic hepatitis C virus infection alters gene expression in chimpanzees

Genome Research - Report proposes initiative to interpret genome data

Genomics and Genetics - Novel siRNA screen identifies genes needed for human cell division

Genomics and Genetics - Open-source program for microarray data visualization released

Geriatrics - Genetic changes observed in aging cells may foreshadow tumorigenesis

Geriatrics - Research must consider separate pathways of mitochondrial populations

Gluconeogenesis - Cytosolic alanine aminotransferases studied, effect of starvation clarified

HIV/AIDS Pathogenesis - HIV-1 Nef mediates neural cell death via IP-10 cytotoxicity

HIV/AIDS Pathogenesis - HIV-1 Vif interacts with dimerization sites of viral protease

HIV/AIDS Pathogenesis - Mechanisms for macrophage-mediated HIV-1 induction investigated

HIV/AIDS Pathogenesis - No correlation between HIV fusion peptides and their membrane affinities

HIV/AIDS Research - HIV receptor expression on ectocervical cells investigated

HIV/AIDS Risk Factors - DC-SIGN promoter polymorphism increases risk of parenteral HIV-1 infection

HIV/AIDS Therapy - Recent studies add new data to HIV/AIDS therapy research

HIV/AIDS Vaccine - Caveolin-1 binding domain of HIV glycoprotein is vaccine candidate

HIV/AIDS Vaccine - Cross-clade CD8 response to HIV-IIIB and Chinese B' and C/B' viruses reported

HIV/AIDS Vaccine - Determinants of HIV escape from primary cytotoxic T cell response

HIV/AIDS Vaccine - Glycoprotein-deficient rabies virus expressing SHIV envelope suppressed SHIV

HIV/AIDS Vaccine - Immunogenic consensus T helper epitopes for HIV vaccine engineered

HIV/AIDS Vaccine - Infectious clone of pediatric HIV clade c isolate identified

HIV/AIDS Vaccine - Neutralization profiles of HIV-1 by monoclonal antibodies presented

HIV/AIDS Vaccine - Occult infection precedes immune response during vaginal SIV inoculations

HIV/AIDS Vaccine - Surface stability and immunogenicity of HIV envelope glycoprotein explored

HIV/AIDS Vaccine - Synapse formation enhances HIV transmission from dendritic to T cells

HIV/AIDS Vaccines - Data advance knowledge in HIV/AIDS vaccines research

Head and Neck Cancer - Photochemical internalization and p53 gene transfer kindle cancer cell death

Head and Neck Cancer - Researchers' work adds to head and neck cancer body of knowledge

Head and Neck Squamous Cell Carcinoma - Report supporting 2-methoxyestradiol and paclitaxel combination published