HIV/AIDS Vaccine
Glycoprotein-deficient rabies virus expressing SHIV envelope suppressed SHIV
Published in Proteomics Weekly, February 14th, 2005
According to recent research published in the Journal of Virology, "Rabies virus (RV) has recently been developed as a novel vaccine candidate for human immunodeficiency virus type 1 (HIV-1). The RV glycoprotein (G) can be functionally replaced by HIV-1 envelope glycoprotein (Env) if the gp160 cytoplasmic domain (CD) of HIV-1 Env is replaced by that of RV G. Here, we describe a pilot study of the in vivo replication and immunogenicity of an RV with a deletion of G (DeltaG) expressing a simian/human immunodeficiency...
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Source: Proteomics Weekly (2005-02-14)
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