Published in Proteomics Weekly, February 14th, 2005
According to recent research published in the journal Molecular and Cellular Biochemistry, "although adenoviral SERCA gene transfer improves cardiac function in the failing heart, there is controversy regarding the cytotoxic effect of such overexpression. We sought to examine the effect of SERCA1 overexpression on neonatal (NRCMs) and adult rat cardiomyocytes (ARCMs)."
"Cultured NRCMs and ARCMs were infected with adenoviral vector expressing enhanced-green fluorescent protein (Ad.EGFP) or SERCA1 (Ad.SERCA1). Gel electrophoresis and microarray analysis were performed to...
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