Oncology

MMP-26 linked to progression of estrogen-dependent malignancies

Published in Proteomics Weekly, February 14th, 2005

Matrix metalloproteinase (MMP)-26 appears to promote the progression of estrogen-dependent malignancies.

"Proteases exert control over cell behavior and affect many biological processes by making proteolytic modification of regulatory proteins," researchers in California explained.

"Alpha1-antitrypsin (AAT) is a serpin, the primary function of which is to regulate the activity of neutrophil/leukocyte elastase," noted W. Li and coauthors at the Burnham Institute in La Jolla. "Insufficient antiprotease activity because of AAT deficiency in the lungs is a contributing factor to early-onset emphysema."

"We recently discovered that AAT...

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Source: Proteomics Weekly (2005-02-14)

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