Protein Kinase

Eosinophil degranulation studied, role of protein kinase C revealed

Published in Proteomics Weekly, February 14th, 2005

According to a study from Kuwait, the activation of a protein kinase inhibits eosinophil degranulation by stimulating intracellular cAMP production.

"The mechanism of inhibition of eosinophil degranulation by protein kinase C (PKC) was investigated in complement C5a (C5a)-stimulated degranulation of highly purified human eosinophils using the specific PKC activator - phorbol 12-myristate 13-acetate (PMA).

"C5a-induced release of eosinophil peroxidase and eosinophil cationic protein was potently inhibited in a concentration-dependent manner by PMA (IC50: 3 and 5 nM, respectively). The inhibition by PMA, but not histamine, was significantly reversed by...

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Source: Proteomics Weekly (2005-02-14)

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