Published in Proteomics Weekly, February 14th, 2005
"Large increases in cytosolic free Ca2+ ([Ca2+](i)) activate several kinases that are important for neuronal plasticity, including Ca2+/calmodulin-dependent kinase II (CaMKII), protein kinase A (PKA), and protein kinase C (PKC).
"Because it is also known, mainly in non-neuronal systems, that superoxide radicals (O2 -) activate these (and other) kinases and because O2 - generation by mitochondria is in part...
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