Phosphatase

Hippocampal neurons studied, role of calcium entry in kinase signaling revealed

Published in Proteomics Weekly, February 14th, 2005

According to a study from the United States, strong calcium entry activates mitochondrial superoxide generation and upregulates kinase signaling in hippocampal neurons.

"Large increases in cytosolic free Ca²⁺ ([Ca²⁺](i)) activate several kinases that are important for neuronal plasticity, including Ca²⁺/calmodulin-dependent kinase II (CaMKII), protein kinase A (PKA), and protein kinase C (PKC).

"Because it is also known, mainly in non-neuronal systems, that superoxide radicals (O₂ ^-) activate these (and other) kinases and because O₂ ^- generation by mitochondria is in part...

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Source: Proteomics Weekly (2005-02-14)

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