Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . March 7th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
Acetylcholine Receptors - Alpha-conotoxins studied, distinct nicotinic acetylcholine receptor sites shown
Amyloid Formation - Amyloid formation analyzed, thermodynamic parameters directly measured
Bacteriology - Melittin analyzed, hemolytic role of leucine zipper motif revealed
DNA - DNA ligase analyzed, influence of replicative clamp loader revealed
Disease Associations - Alpha-synuclein studied, influence of C-terminal domain on aggregation revealed
Actin - Actin polymerization analyzed, force-driven mechanism indicated
Actin - Actin-destabilizing factors studied, nature of filaments disruption revealed
Addiction Medicine - Research identifies proteins crucial to brain's information superhighway
Adenoviral Vectors - Adenoviral vectors used, CFTR expression and properties clarified
Adiposity - Promethin and PGLP are genes up-regulated in adipogenic livers
Aggregated Proteins - Mediated solubilization of aggregated proteins; unfolded polypeptides involved
Alcohol Use - Whisky reduces tryptophan availability to brain
Alzheimer Disease - Effects of caspase cleavage on tau function and aggregation clarified
Alzheimer Disease - Rat brain proteins may mediate neuroprotective actions of grape seed extract
Amyloid Polyneuropathy - Variability in disease caused by interaction of several genes
Angiology - CGRP-induced responses in subcutaneous arteries studied, antogonism revealed
Angiology - Celecoxib uses multiple signaling mechanisms to suppress neovascularization
Angiology - Recent findings in angiology provide new insights
Antioxidants - Novel class of chain-breaking antioxidants synthesized, reactivity reported
Apolipoprotein - Apolipoprotein studied, effect on vascular smooth muscle cell clarified
Apoptosis - Gpx4 plays a role in the mechanism of apoptosis induced by oxidative stress
Apoptosis - Histatin analyzed, inhibition of apoptosis in human gingival fibroblasts shown
Atherosclerosis - Angpt13 may be involved in atherosclerosis susceptibility in mice and humans
Atherosclerosis - Findings advance knowledge in atherosclerosis research
Atherosclerosis - Linoleic acid studied, role in monocyte deformation and adhesion revealed
Atherosclerosis - Trial of RUS 3108 begin in Ireland
Bacteriology - Expression of plasminogen activator achieved by inducing stress responses
Bacteriology - Role of C. albicans dynein heavy-chain gene elucidated
Bacteriology - TLR2 recognizes sBLP - a bacterial lipopeptide - through direct binding
Beta-Arrestin - Beta-arrestin analyzed, activation-dependent conformational changes revealed
Biochemistry - Novel tripodal receptor developed for molecular monosaccharide recognition
Bioinformatics - Graphical user interface devised for linear modeling of microarray data
Biomedical Engineering - Nanobiohybrids implement fluorescent protein transfection
Biomedicine - Data mining in biomedicine realized by using digital and molecular libraries
Biotechnology - On-chip free-flow magnetophoresis effective for magnetic particle separation
Bioterrorism - Biotechnology company working on vaccine development against bioterror agents
Bladder Cancer - New test improves detection of bladder cancer
Bladder Cancer - Panel of tumor markers may improve diagnostic tests
Bovine Thyroglobulin - Bovine thyroglobulin studied, nature of multimerization clarified
Breast Cancer - Gene signature can predict metastasis
Breast Cancer - Recent findings in breast cancer provide new insights
Brucella - Genetic bases of rifampin resistance in Brucella reported
Business & Finance - Dermagenetics maker retains Equitilink, LLC, for investor relations
Business Update - ExonHit launches SpliceArray Service with GPCR and ion channel microarrays
Business Update - GeneBio inks agreement for the distribution of Phenyx MS software platform
Business Update - Glaxo makes $1.0 million payment, starts phase 2 studies of oral platelet drug
Business Update - Maker of genetic analysis devices expands sales efforts into Canada
Business Update - Technology company signs supply agreement with Roche Molecular Systems
COX-2 Inhibitors - Findings provide insight on reported differences in CV risk for COX-2 inhibitors
Calbindin - Calbindin studied, calcium transport in developing teeth clarified
Calcium Binding - Ca2+ ion binding studied, positive cooperativity revealed
Calcium Channels - Calcium channels studied, role of voltage gating in aldosterone secretion found
Calcium Signaling - PIP5KI gamma87 studied, requirement in Ca2+ signaling revealed
Cancer Diagnosis - VEGF is not a satisfactory prognostic marker for breast cancer patients
Cancer Research - Cysteine cathepsins allowed the invasion of AdoMetDC-transformed rodent cells
Cancer Therapy - BCL-2 inhibition sensitizes malignant cells to cancer immunotherapy
Cancer Therapy - New data illuminates research in cancer therapy
Cancer Therapy - Resveratrol displayed chemopreventive effects
Cancer Therapy - ZD6474 arrests the growth of gefitinib-sensitive tumors
Cancer Vaccines - Studies advance knowledge in cancer vaccines research
Canine Distemper Virus - Hemagglutinin gene of canine distemper viruses analyzed
Cardiology - CD28 peptidemimic prolongs survival of cardiac allografts
Cardiology - Efforts to block PAI-1 revitalize cardiac function after ischemic insult
Cardiology - Endothelin-1 enables cardiac cells to tolerate hypoxia
Cardiology - Reports advance knowledge in cardiology research
Cardiology - Researchers detail new studies and findings in the area of cardiology
Cardiomyocytes - MURF1 can blunt cardiomyocyte hypertrophy
Cardiovascular Disease - CD73 plays key role in hypoxia-induced vascular leakage
Cardiovascular Research - Endothelin-B receptors help control vascular reactivity to endothelin-1
Cardiovascular Research - Study examined the structural diversity among ET-2/VIC orthologs
Cardiovascular Research - Study investigated signaling mechanism of C. pneumoniae in human fibroblasts
Cardiovascular Research - p38 inhibition may be an approach to attenuate inflammation in CV disease
Cell Biology - Critical role in programmed cell death identified
Cell Biology - Human Zwint-1 plays key role in mitotic checkpoint signaling
Cell Biology - Method helps stem cells maintain their humanity
Cell Biology - New research questions basic tenet of neuron function
Cell Biology - Novel interferometry assay enables nanoscale molecular interaction analysis
Cell Biology - Scientists share new insights into muscle growth regulation
Cell Differentiation - Signaling pathway analyzed, positive role in PC12 cell differentiation revealed
Cell Signaling - Inhibition of gallbladder contractility, role of ions clarified
Cloning - pTOC-T vector constructed by using GST-ParE toxin for direct cloning
Collaborations - Companies sign alliance program for protein kinase target
Collaborations - Research collaboration agreement signed
Collagen - Arterial smooth muscle cells studied, functional role of homocysteine clarified
Colon Cancer - Ritonavir may curb colon carcinogenesis via apoptosis/inflammatory modulation
Colorectal Cancer - Overexpression of KCNK9 may play role in development
Complementary & Alternative Medicine - Pu-erh tea analyzed, influence on physiological damage clarified
Complementary & Alternative Medicine - Radix astragali astragaloside IV studied, properties clarified
Compstatin - Compstatin analyzed, thermodynamics of interaction with complement revealed
Creutzfeldt-Jakob Disease - Diagnosis of prions in patients should utilize novel strategy
Cystic Fibrosis - CFTR biogenic intermediate studied, conditions of accumulation clarified
Cystic Fibrosis - Cystic fibrosis channel pore analyzed, role of different regions shown
Cytomegalovirus Vaccines - Findings describe new data in cytomegalovirus vaccines research
DNA - Yeast high mobility group box protein studied, role in DNA binding revealed
DNA Ligase - Escherichia coli DNA ligase studied, temperature sensitivity characterized
DNA Repair - Cohesin studied, influence in DNA repair clarified
DNA Research - Escherichia coli RecA complex studied, crystal structures obtained
Dendritic - DC-SIGN tetramers essential for high affinity interactions with HIV
Dendritic Cell Vaccine - Apoptosis of monocytes influences yield of dendritic cells
Dendritic Cell Vaccine - Transcriptional regulation of dectin-2 promoter investigated
Dengue Fever - New findings in dengue fever described
Dermatology - Desmoglein 4 gene mutations correlate with hypotrichosis in lanceolate models
Developmental Biology - Wnt signaling protein acts in the nucleus, not just in the cytoplasm
Diabetes Complications - Amyloid peptide channels play role in diabetes complications
Diabetes Genomics and Genetics - Idd1 and Idd3 needed for development of type 1 diabetes
Diabetes Genomics and Genetics - Inactive ALDH2 genotype linked to maternal inheritance of diabetes
Diabetes Genomics and Genetics - Prevention of type 2 diabetes from viewpoint of genetics presented
Diabetes Genomics and Genetics - Risk of type 1 diabetes predicted from polymorphisms in candidate genes
Diabetes Pathogenesis - ATP synthase functions as fuel sensor in pancreatic beta cells
Diabetes Pathogenesis - Cytokines activate caspase-3 in insulinoma cells of diabetes-prone mice
Diabetes Pathogenesis - IA-2 antibodies linked to increased risk of type 1 diabetes
Diabetes Pathogenesis - Impaired response to glucose load linked to low glucose storage
Diabetes Pathogenesis - Protein kinase activation increases insulin secretion
Diabetes Pathogenesis - Recent findings in diabetes pathogenesis described
Diabetes Pathogenesis - Researchers describe findings in diabetes pathogenesis studies
Diabetes Pathogenesis - Studies advance knowledge in diabetes pathogenesis research
Diabetes Pathogenesis - Type 2 diabetes with high levels of C peptide reported
Diabetes Therapy - Molecular therapeutic target for type 2 diabetes reported
Diabetes Therapy - Preventing type 1 diabetes from viewpoint of beta-cell damage outlined
Diabetes Therapy - Sulfonylurea and non-sulfonylurea hypoglycemic agents reviewed
Diabetes Therapy - Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice
Diabetic Nephropathy - Advanced glycation end products important in diabetes complications
Diabetic Nephropathy - Researchers report details of new studies and findings in the area of diabetic nephropathy
Diabetic Neuropathy - Adipocytokines contribute to diabetic neuropathy
Diabetic Neuropathy - Diabetes induces expression of activating transcription factor 3
Diabetic Neuropathy - Kinin B-1 receptors expressed in spinal cord of diabetic rats
Diabetic Neuropathy - Reports advance knowledge in diabetic neuropathy research
Diabetic Neuropathy - Studies advance knowledge in diabetic neuropathy research
Diagnostics - LightCycler polymerase chain reaction can diagnose fungal infections
Diagnostics - Transcriptional-based screens detect endothelial cell gene products
Diarrhea Vaccine - Antibody binding linked to activity of F4 fimbrial adhesin FaeG
Diet and Nutrition - Dietary fatty acids have dissimilar effects on genes in the rodent liver
Disease Associations - Staphylococcus aureus lipoprotein studied, binding behavior shown
Disease Associations - Influenza A virus PB1-F2 protein studied, mitochondrial function revealed
Disease Associations - Ulcerative colitis studied, pathogenic role of costimulatory molecules clarified
Drug Delivery - Introns are required for prolonged apolipoprotein A-I transfection
Drug Delivery - Market research company announces report on CNS diseases and drug delivery
Drug Delivery - Non-viral vectors make efficient antisense oligonucleotide delivery systems
Drug Delivery - Reports describe recent advances in drug delivery research
Drug Development - An oncolytic DNA-alkylating drug for treatment of solid tumors shows promise
Drug Development - Bioactive peptide conjugates characterized using thioether linkages
Drug Development - Phenylalanine aminomutase analyzed and cloned
Drug Development - Protein microarray chips unearth new peptides with therapeutic potential
Drug Metabolism - Novel CYP2A6 allele alters nicotine metabolism in black carriers
Drug Resistance - Biliary cirrhosis studied, bezafibrate induction of multidrug resistance shown
Embryogenesis - Mitochondrial SDHD gene required for early embryogenesis
Encephalitis - Gene dysregulation found in cortex of HIV encephalitis patients
Endocrinology - Melanin-concentrating hormone regulates LHRH release in female rats
Endocytosis - T cell receptors analyzed, differential down-modulation revealed
Endothelium - Uterine endothelium studied, relaxant effect of vasoactive polypeptide shown
Energy Expenditure - Melanocyte stimulating hormone increases resting metabolic rate
Enterococcus Vaccine - Rationale for developing immunotherapy against enterococci presented
Environmental Biotechnology - DNA microarray chip developed to detect sludge bacteria
Environmental Health - Cellular gene expression changes induced by copper overload identified
Enzymology - Alcaligenes xylosoxidans nitrate reductase mutants studied, insights gained
Enzymology - Differences in the lab protocols lead to large variation of results
Enzymology - Dihydrofolate reductase studied during catalysis, conformational changes noted
Enzymology - KRN633 eliminates angiogenic growth in solid tumors
Enzymology - Proteases mark the survival of node-negative breast cancer
Enzymology - Recent findings illuminate research in enzymology
Enzymology - Reports add new data to enzymology research
Esophageal Cancer - Esophageal adenocarcinoma cells treated with hemocyanin examined
Estrogen - Brain lipid peroxidation studied, protective effect of estrogen revealed
Ezrin-Radixin-Moesin - Ezrin-radixin-moesin studied, role of binding protein clarified
Fetal Medicine - Technique identifies fetal genetic material from amniotic fluid
Fibronectin - Fibronectin analyzed, integrin-dependent functional domains identified
Finance - Biotech reports 2004 revenues of $410.4 million
Finance - Pharmaceutical company reports fourth quarter and year-end results
Finance - Pharmacogenomic-focused pharma reports increased revenues and losses in 2004
Finance - Research organization posts record 2004 revenues
Food Safety - Genomics provided new insight on microbial food safety
Gastroenterology - Entamoeba histolytica studied, role in erythrocyte digestion clarified
Gastroenterology - Angiogenin may influence the pathogenesis of inflammatory bowel disease
Gastroenterology - Vasoactive growth factors augment the healing of gastric ulcers
Gene Research - BLM gene interactions are detected in human cells
Gene Research - Gene profiles delineate the phenotypic character of human disease
Gene Research - Mammalian cortistatin is analogous to a non-mammalian somatostatin variant
Gene Research - Non-specific silencing complicates the use of small interfering RNA
Genomics and Genetics - MEF2-regulated genes during muscle differentiation identified
Genomics and Genetics - Molecules that mediate innate immune recognition discovered
Geriatrics - Humans display age and cataract-specific gene changes in the lens
Gestation - Dentate gyrus potentiation analyzed, role of infuled benzo(A)pyrene shown
Glioma Therapy - Selective estrogen receptor modulators induce glioma cell apoptosis
Glutathione Transferases - Regulation of GSTs in Schizosaccharomyces pombe clarified
Glycoprotein - P-glycoprotein studied, role in brain uptake of dextromethorphan revealed
Growth Factor Receptors - Nerve growth factor receptor signaling studied, effects revealed
Gynecology - Endothelin receptor blockade may eliminate COX-2-associated ovarian cancer
HIV/AIDS Opportunistic Infection - C-18 mutations critical for CCR5-binding/HIV-1 fusion inhibition
HIV/AIDS Pathogenesis - HIV-1 can dysregulate CD4+ T cells that express CXCR4
HIV/AIDS Pathogenesis - SOCS box in HIV-1 Vif that mediates its interaction with ElonginC characterized
HIV/AIDS Research - APOBEC3B and APOBEC3C are potent inhibitors of SIV replication
HIV/AIDS Research - SOCS-box phosphorylation regulates assembly of HIV-1 Vif-Cul5 complex
HIV/AIDS Therapy - Drugs to inhibit drug-resistant HIV reverse transcriptases developed
HIV/AIDS Therapy - Studies describe new findings in HIV/AIDS therapy research
HIV/AIDS Vaccine - Conformational changes during T cell receptor engagement reported
HIV/AIDS Vaccines - Recent findings in HIV/AIDS vaccines described
Haemophilus Vaccine - Antibodies against Haemophilus parasuis characterized
Hematology - GM-CSF regulates soluble VEGF receptor-1 and angiogenesis in mice
Hematology - Researchers detail new studies and findings in the area of hematology
Heparin - Practical use of generic low-molecular-weight heparins reviewed
Hepatocellular Carcinoma - Clusterin overexpression has prognostic value
Hepatocyte Growth Factor - Recombinant hepatocyte growth factor studied, pharmacokinetics clarified
Hepatology - Beta2 -glycoprotein I inhibits liposome uptake by liver cells
Hereditary Angioedema - Companies sign manufacturing agreement for recombinant human C1 inhibitor
Histamine - Histamine receptor studied, nature of phosphorylations clarified in intact cells
Hormone Replacement Therapy - Research sheds light on why estrogens produce unintended results in women
Huntington Disease - Intrabodies confront dysfunctional protein activity
Hyperparathyroidism - Hyperparathyroidism studied, oxacalcitriol dose-response revealed
Imidazole - Formamidopyrimidine-DNA glycosylase studied, active site behavior clarified
Immunology - CD4 mimicry by anti-idiotypic antibody based on conformational epitope
Immunology - Innate immune responses during infection reviewed
Immunology - Novel CD200 receptor-like protein identified on basophils and mast cells
Infections - Bacillus cereus Nhe enterotoxin characterized
Inflammation - Beta-adrenergic receptor studied, neutrophil regulation clarified
Inflammatory Disease - Alpha1-antitrypsin gene deficiency in mice resembles human fetal disease
Influenza - Haemophilus influenzae studied, haem-utilization protein identified
Information Technology - 600-CPU PatternHunter license granted to Stanford University
Insulin Resistance - Pro12Ala polymorphism of PPAR-gamma gene linked to insulin resistance
Ion Channel - Dirofilaria immitis studied, ligand-gated ion polypeptide identified
Kaposi Sarcoma-Associated Herpesvirus - E2-binding C4HC3-type RING domain identified in KSHV K3N-terminal domain
Kaposi Sarcoma-Associated Herpesvirus - New research in the area of kaposi sarcoma-associated herpesvirus detailed
Leukemia - Vaccine may complement conventional treatment for chronic leukemia
Lipid Studies - Genes involved in human lipid metabolism identified
Liver Cancer - Researchers provide details of new studies and findings in the area of liver cancer
Low-Density Lipoproteins - Low-density lipoprotein studied, conditions inducing chemokine release shown
Lung Cancer - Blocking estrogen may be crucial to lung cancer survival
Malaria - Histidine-rich protein-based malaria drug assay developed, field use reported
Malaria - New data illuminates research in malaria
Malaria Vaccine - Alanine-rich repeats are intact in Plasmodium falciparum MSP3
Malaria Vaccine - Allelic dimorphism found in surface protein of Plasmodium vivax
Malaria Vaccine - Sequence diversity of P. falciparum merozoite protein reported
Malaria Vaccines - Researchers describe findings in malaria vaccines studies
Malaria Vaccines - Studies advance knowledge in malaria vaccines research
Matrix Metalloproteinases - Chronic allograft rejection studied, predictors identified
Matrix Metalloproteinases - Matrix metalloproteinase expression studied, role of oxidative stress revealed
Melanoma - Firefly protein illuminates virus' hunt of metastasized melanoma cells
Melanoma - Microtubule-dependent MMP-2/MMP-9 exocytosis needed for cell invasion
Melanoma Vaccines - Data advance knowledge in melanoma vaccines research
Membrane Topology - Acid-sensing ion channel 2a analyzed, membrane topology clarified
Mental Health - New regulatory mechanism discovered that inhibits HDAC activities in disease
Mental Health - Stress-induced expression of MC4R gene in the amygdala and hypothalamus
Metabolic Syndrome - Researchers' work adds to metabolic syndrome body of knowledge
Metabolic Syndrome - Scientists show knocking out two key signals will cause diabetes
Metastases - Study shows naturally occurring proteins protect against rapid tumor growth
Metastatic Melanoma - Special protocol assessment for trial of metastatic melanoma treatment completed
Motility - Myxococcus xanthus motility mutant studied, nature of motility clarified
Mutagenesis - Aipl1-deficient mice model a disorder that causes pediatric blindness
Mycoplasma - PCR method for mycoplasma testing of cell cultures developed
Nanotechnology - Nano mechanism to control protein may lead to new protein engineering
Natural Products - ESPS elevated soybean production
Neonatal Diabetes - Molecular basis neonatal diabetes explored
Nephrology - Scientists identify potential therapy for kidney failure
Nephrology - Sp1 activation is crucial for claudin-19 gene expression in kidney cells
Nephrology - Study examined effects on TGF-beta1 release in peritoneal cells
Neural Stem Cell Research - Endoneurial fibroblasts are derived from neural crest
Neural Stem Cell Research - Oligodendrocyte conversion to NSLC depends on progressive chromatin remodeling
Neural Stem Cell Research - Pergolide protects against levodopa-induced cytotoxicity of neural stem cells
Neural Stem Cell Research - Programmed cell death of adult-generated hippocampal neurons mediated by Bax
Neuroblastoma - N-Myc and H-Twist cooperation linked to oncogenesis
Neuroblastoma - PVR expression influences tumor cell susceptibility to NK cells
Neurodegeneration - Genetic fingerprints exemplify type 2 Gaucher disease
Neurology - Nurr1 expression studied in the brain, effect of chronic lithium revealed
Neuroscience - Bioinformatics and gene profiles join to analyze the developing brain
Neuroscience - Brain synapse formation linked to proteins
Neuroscience - GABARAP transports GABAA receptors to neuron plasma membrane
Neuroscience - HIV-1 downregulates genes associated with neuronal integrity
Neuroscience - Nkx6-2 transcriptional activity needed for normal myelin paranode structure
Neuroscience - Vasopressin and dopamine production modulate male social behavior
Noonan Syndrome - Mouse model of leukemia yields therapeutic implications for rare cancer
Notch Signaling - Notch studied, adhesion force and rate of signaling revealed
Nuclear Membrane - Nuclear pore-directed transport of proteins studied, conditions clarified
Nutrition - Oral lactose-ureide studied, N-15 transfers to lysine revealed
Obesity Pathogenesis - Electrophysiology of feeding circuits outlined
Obesity Pathogenesis - Researchers publish new studies and findings in the area of obesity pathogenesis
Obesity Therapy - MC4 receptor shows promise as therapeutic target for obesity
Obesity and Diabetes - Protein kinase C interactions in adipocytes regulate glucose uptake
Obesity and Diabetes - Signal pathway regulating plasminogen activator inhibitor identified
Olfactory Receptors - Olfactory receptor neurons studied, role of Bcl-2 expression revealed
Oncology - Angiogenic protein levels differentiate malignant and nonmalignant ascites
Oncology - Antisense molecules targeting alpha folate receptor hinder breast cancer cells
Oncology - Data advance knowledge in oncology research
Oncology - Protein with key role in cytokinesis is regulated by p53
Oncology - Recent findings illuminate research in oncology
Oncology - Studies add new findings to oncology body of knowledge
Oncology - Studies advance knowledge in oncology research
Oral Cancer - Cyclin G2 dysregulation linked to oral oncogenesis
Ovarian Cancer - Another look finds promising proteomics test is not biologically plausible
Ovarian Cancer - New findings in the area of ovarian cancer described
Ovarian Cancer - Serum proteomics technology debated
Pancreatic Cancer - Novel putative protein biomarkers and therapeutic targets identified
Pancreatic Islets - Adenoviral overexpression protects pancreatic islets from oxidation
Peptide Fragments - Mercaptoethyl amino acids synthesized, potential as building blocks clarified
Peroxisome - Peroxisome membrane actin organization studied, role for Rho1p shown
Personnel - Dale A. Sander joins protein-therapeutics company as CFO and senior VP
Personnel - Protein-focused biopharmaceutical company appoints Theresa Heggie as GM, Europe
Personnel - Protein-focused biotech company names Dartmouth cancer researcher to board
Phosphate Transporter - Structural modeling made of dual-affinity purified Pho84 phosphate transporter
Phosphodiesterase - Phosphodiesterase inhibitor analyzed, osteoclast formation stimulated
Phototropin Kinase - LOV-J alpha helix interaction studied, effects on phototropin kinase revealed
Physical Activity - Exercise induces tissue-specific change in endothelin-1 expression
Physiology - Phaffia rhodozyma characterized, influence of gamma-irradiation clarified
Physiology - Organ of Corti studied, evidence for resonant electromechanical force revealed
Physiology - PARP-1 analyzed, NAD(+)-dependent modulation of chromatin structure revealed
Physiology - Rhizobium regulatory protein studied, nature of operator binding clarified
Physiology - Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase
Physiology - Subunit of IIFN receptor complex studied, nuclear localization sequence shown
Physiology - Vitamin E metabolites studied, functional comparisons undertaken
Pleckstrin - Pleckstrin homology domain studied, activation parameters clarified
Prions - Copper-binding chimera studied, de novo design revealed
Prodrug - Acyclovir studied, bioavailability and transport in Caco-2 cells revealed
Prostate Cancer - High heterogeneity found in metastatic hormone-resistant disease
Prostate Cancer - Molecular antitumor activity of vitamin D characterized
Prostate Cancer - S100A11 may play role in prostate tumor development
Protein Expression - Targeted in vivo expression of proteins in the calyx of Held reported
Protein Folding - Lysozyme refolding analyzed, influence of macromolecular crowding clarified
Protein Regulation - Mechanical stretch upholds the angiogenic potential of CCN1
Protein Signal - Signal transduction modulation through PrPc linked to lipid raft incorporation
Protein Signaling - Nuclear fibroblast growth factor-2 studied, specific interaction revealed
Protein Signaling - WRKY gene from creosote bush studied, abscisic acid signaling activator shown
Proteomics - Core protein processing varies with hepatitis C virus genotype
Proteomics - Data variance in quantitative 2D electrophoresis characterized
Proteomics - Exercise causes time-related enhancement of gene expression of ET-1
Proteomics - Human PTIP maintains genome stability
Proteomics - Ligand binding assay incorporated into centrifugal microfluidics platform
Proteomics - Novel microfluidic mixer facilitates study of protein folding
Proteomics - Protein can help doctors predict how dangerous clogged arteries will be
Proteomics - Rapid method analyzes ET-A and ET-B receptor gene expression levels
Proteomics - Research add new data to proteomics body of knowledge
Proteomics - Researchers' work adds to proteomics body of knowledge
Proteomics - Staufen 1 ribonucleoprotein complexes characterized
Proteomics - Study examined effects of ET-1 and aldosterone on COX-2 gene expression
Pseudomonas Vaccine - Vaccine against Pseudomonas aeruginosa infection developed
Pulmonary Medicine - MMP1 gene polymorphism associates with chronic obstructive pulmonary disease
Pulmonary Medicine - Survivin and p53 modulate the influence of quercetin on lung cancer cells
RecA Protein - RecA function probed, competing modulation by DinI and RecX revealed
Receptor Studies - ET-1 antinociceptive effect involved descending pain inhibitory system
Receptor Studies - ET-A and ET-B receptors exist as constitutive homodimers
Receptor Studies - Novel system improves cannabinoid receptor 2 purification
Receptor Studies - VPAC1 , VPAC2 , and PAC1 receptors in human tissues identified
Reproductive Medicine - WAVE1 intranuclear trafficking required for fertilization
Respiratory Medicine - Ultrasonic nebulization supports polyplex stability during aerosolization
Retinal Degeneration - Recessive NRL mutations studied, association with retinal maladies revealed
Rhodopsin - Rhodopsin Schiff base structure and function studied, hydrogen bonds implicated
Ribonuclease - Ribonuclease T1 analyzed, thermal unfolding revealed
Spinal Muscular Atrophy - Researchers describe findings in spinal muscular atrophy studies
Staphylococcal Infection - S. aureus adherence to fibronectin elucidated
Staphylococcus Vaccine - Glucosamine polysaccharide shows promise for staphylococcal vaccine
Staphylococcus Vaccine - Humanized antibody targeting Staphylococcus aureus developed
Stem Cell Research - Phosphophoryn regulates MSC gene expression via integrin/MAPK signaling pathway
Streptococcus Vaccine - Host-pathogen interactions of Streptococcus pyogenes reviewed
Synapses - Vesicular reuptake studied, inhibition by synaptotagmin domain antibody shown
Systemic Lupus Erythematosus - Peptide ameliorates lupus manifestations
Tabacco Use - Genotoxicity of tobacco smoke and tobacco smoke condensate reviewed
Thioredoxin - Dictyostelium discoideum thioredocin targets shown, properties revealed
Thioredoxin Reductase - Thioredoxin reductase studied, role in growth of lens epithelial cells revealed
Tobacco Use - Transcriptional effects of nicotine determined in five brain regions
Topoisomerase - Topoisomerase terminal domain analyzed, role in catalysis implied
Toxicology - Dioxin has weak estrogenic activity in the uterus
Transfer Proteins - Phosphatidylinositol transfer proteins studied, phosphorylation sites implicated
Transfusion Medicine - Novel sulfide-binding mechanism found in deep-sea tubeworms
Transgenics - CTP:phosphocholine cytidylyltransferase over-expression studied, effects shown
Transgenics - Green fluorescent protein transgenic mice selected, technique described
Transplant Medicine - Gene profiles show fractalkine plays a role in kidney allograft rejection
Tuberculosis Vaccine - DNA vaccine protects mice against primary TB infection
Vaccine Development - Host cell-pathogen interfaces reviewed
Vaccine Efficacy - scFv reactivity enhanced after mixing with anti-tag monoclonal antibody
Varicella-Zoster Vaccine - Genetic profile of Oka varicella vaccine virus variant presented
Vector Development - Low-pressure chromatography synthesizes PEG-peptides for gene delivery
Virology - Hepatitis B virus genotype D backs aggressive liver disease
Virology - Recent findings illuminate research in virology
Virology - Recombinant adenoviruses initiate complement activation
Virology - Retroviruses transduce embryonic stem cell-derived hematopoietic progenitors
Yarrowia Lipolytica - Yarrowia lipolytica shows potential in study of phosphate transport systems
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