Diabetes Therapy
Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice
Published in Proteomics Weekly, March 7th, 2005
According to a study from Japan, "Non-obese diabetic (NOD) mice develop diabetes mediated by pathogenic T-helper type 1 (Th1) cells. Valpha14 Natural killer (NKT) cells are a unique lymphocyte subtype implicated in the regulation of autoimmunity and a good source of protective Th2 cytokines. We recently developed a Th2-skewing NKT cell ligand, OCH. OCH, a sphingosine truncated derivative of alpha-galactosylceramide (alphaGC, stimulates NKT cells to selectively produce Th2 cytokines."
"Here we show that OCH prevented the development of diabetes and insulitis in...
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Source: Proteomics Weekly (2005-03-07)
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