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Acyclovir studied, bioavailability and transport in Caco-2 cells revealed

Published in Proteomics Weekly, March 7th, 2005

Recent research from Denmark published in the European Journal of Pharmaceutical Sciences compared the in vivo bioavailability and Caco-2 cell transport of acyclovir.

"It has previously been shown that the prodrug Glu(acyclovir)-Sar has a high affinity for PEPT1 in Caco-2 cells. However, affinity does not necessarily lead to translocation by the transporter, which is necessary for achieving an increased oral bioavailability," wrote A.E. Thomsen and colleagues, Danish University of Pharmaceutical Science.

"Therefore i.v. and p.o. doses of Glu(acyclovir)-Sar, acyclovir and valacyclovir were given to rats and the collected blood samples were...

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Source: Proteomics Weekly (2005-03-07)

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