Published in Proteomics Weekly, March 7th, 2005
"It has previously been shown that the prodrug Glu(acyclovir)-Sar has a high affinity for PEPT1 in Caco-2 cells. However, affinity does not necessarily lead to translocation by the transporter, which is necessary for achieving an increased oral bioavailability," wrote A.E. Thomsen and colleagues, Danish University of Pharmaceutical Science.
"Therefore i.v. and p.o. doses of Glu(acyclovir)-Sar, acyclovir and valacyclovir were given to rats and the collected blood samples were...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Proteomics Weekly